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Purpose <p>Smokers with squamous cell carcinoma (SCC) of the tongue may be particularly prone to experience multifactorial gustatory dysfunction. This study investigates the effects of heavy smoking on taste perception in patients undergoing glossectomy type IIIa (i.e. non-compartment hemiglossectomy) for SCC of the tongue.</p> Methods <p>Gustatory function was assessed in 30 heavy-smoking patients with SCC of the tongue using a validated taste strips test. Psychophysical evaluations were conducted at baseline and at 3, 6, 9, and 12 months post-surgery.</p> Results <p>At baseline, mean taste strip scores (TSS [SD]) were significantly lower in patients compared to controls (8.7 [1.9] vs. 11.6 [2.1], <i>P</i> &lt;.001). Post-treatment, TSS in patients declined to 7.2 [1.0] at 3 months, followed by a gradual recovery to 7.6 [2.3] at 6 months, 8.4 [2.8] at nine months, and 8.9 [3.9] at 12 months. Patients who quit smoking achieved significant recovery, with TSS improving from 7.4 [0.9] at three months to 11.8 [1.4] at twelve months, nearing control values. In contrast, smokers experienced a progressive decline, from 6.8 [1.2] at three months to 4.6 [1.6] at twelve months (<i>P</i> &lt;.001). Adjuvant radiotherapy exacerbated short-term deficits (TSS of 6.6 [1.0] vs. 7.5 [0.9], <i>P</i> =.027 at three months) but showed no significant long-term impact.</p> Conclusion <p>Persistent smoking worsens taste perception and impedes recovery in patients undergoing glossectomy type IIIa for tongue SCC. Smoking cessation significantly enhances sensory restoration, underscoring its importance in post-treatment care.</p>

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Effects of smoking cessation on taste function in heavy smokers undergoing hemiglossectomy for tongue squamous cell carcinoma

  • 期刊论文

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  • 发表日期：

    2025年7月23日

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  • Paolo Boscolo-Rizzo,
  • Thomas Hummel,
  • Alberto Vito Marcuzzo,
  • Antonino Maniaci,
  • Giacomo Spinato,
  • Luca Raimondo,
  • Luigi Angelo Vaira,
  • Rachele Tulissi,
  • Anna Menini,
  • Franco Trabalzini,
  • Enzo Emanuelli,
  • Vittorio Grill,
  • Jerry Polesel,
  • Fabiola Giudici,
  • Giancarlo Tirelli

摘要

Purpose

Smokers with squamous cell carcinoma (SCC) of the tongue may be particularly prone to experience multifactorial gustatory dysfunction. This study investigates the effects of heavy smoking on taste perception in patients undergoing glossectomy type IIIa (i.e. non-compartment hemiglossectomy) for SCC of the tongue.

Methods

Gustatory function was assessed in 30 heavy-smoking patients with SCC of the tongue using a validated taste strips test. Psychophysical evaluations were conducted at baseline and at 3, 6, 9, and 12 months post-surgery.

Results

At baseline, mean taste strip scores (TSS [SD]) were significantly lower in patients compared to controls (8.7 [1.9] vs. 11.6 [2.1], P <.001). Post-treatment, TSS in patients declined to 7.2 [1.0] at 3 months, followed by a gradual recovery to 7.6 [2.3] at 6 months, 8.4 [2.8] at nine months, and 8.9 [3.9] at 12 months. Patients who quit smoking achieved significant recovery, with TSS improving from 7.4 [0.9] at three months to 11.8 [1.4] at twelve months, nearing control values. In contrast, smokers experienced a progressive decline, from 6.8 [1.2] at three months to 4.6 [1.6] at twelve months (P <.001). Adjuvant radiotherapy exacerbated short-term deficits (TSS of 6.6 [1.0] vs. 7.5 [0.9], P =.027 at three months) but showed no significant long-term impact.

Conclusion

Persistent smoking worsens taste perception and impedes recovery in patients undergoing glossectomy type IIIa for tongue SCC. Smoking cessation significantly enhances sensory restoration, underscoring its importance in post-treatment care.