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Introduction <p>Empty nose syndrome (ENS) is a complex iatrogenic condition resulting from excessive inferior turbinate resection, leading to paradoxical nasal obstruction despite an objectively patent airway.</p> Methods <p>This system review and meta-analysis of meta-analyses, performed with the AMSTAR2 tool, evaluates surgical treatment outcomes for ENS, focusing on validated patient-reported measures such as the ENS6Q and SNOT questionnaires.</p> Results <p>Data from three meta-analysis, including over 1500 cases, highlights the long-term benefits and limitations of various surgical approaches.</p> Discussion <p>While surgical interventions demonstrate sustained improvements in patient quality of life, substantial heterogeneity across meta-analyses and overlapping primary data highlight the need for standardized protocols, harmonized outcome measures, and meta-evaluation frameworks in future ENS research.</p>

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Surgical interventions for empty nose syndrome: A meta-analysis of meta-analyses

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月3日

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  • Leire Aguirre-Peña,
  • Octavio Garaycochea,
  • Isam Alobid,
  • Holger Sudhoff,
  • Manuel Bernal-Sprekelsen

摘要

Introduction

Empty nose syndrome (ENS) is a complex iatrogenic condition resulting from excessive inferior turbinate resection, leading to paradoxical nasal obstruction despite an objectively patent airway.

Methods

This system review and meta-analysis of meta-analyses, performed with the AMSTAR2 tool, evaluates surgical treatment outcomes for ENS, focusing on validated patient-reported measures such as the ENS6Q and SNOT questionnaires.

Results

Data from three meta-analysis, including over 1500 cases, highlights the long-term benefits and limitations of various surgical approaches.

Discussion

While surgical interventions demonstrate sustained improvements in patient quality of life, substantial heterogeneity across meta-analyses and overlapping primary data highlight the need for standardized protocols, harmonized outcome measures, and meta-evaluation frameworks in future ENS research.