Scholarlink

Objective <p>Research on age and prognosis for oral cavity squamous cell carcinomas (OSCCs) has shown inconsistent results. We aimed to establish age as an independent prognostic factor and determine an age cutoff for staging in OSCC.</p> Methods <p>Electronic records were reviewed for all OSCC patients treated between 2000 and 2020.</p> Results <p>The study involved 250 patients, identifying a mortality cutoff age of 65 through Receiver Operating Characteristic curve analysis (sensitivity 77%, specificity 49%). Patients ≥ 65 had lower survival rates for early-stage (TNM I-II; 63.5% vs. 96%, <i>p</i> &lt; 0.001) and advanced-stage (TNM III-IV; 37.5% vs. 62%, <i>p</i> = 0.011) diseases. A proposed age-based TNM staging system categorized ≥ 65 as Stage III/IV, with comparable survival rates confirmed in a revised analysis.</p> Conclusion <p>The study identifies age, with a 65-year cutoff, as an independent prognostic factor in OSCC and highlights its role in improving current staging systems.</p> Level of evidence <p>III.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Reappraising the TNM staging system for oral cavity squamous cell carcinoma: an age-related prognosis analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月25日

查看全文
  • Amit Ritter,
  • Eyal Yosefof,
  • Nofar Edri,
  • Noga Kurman,
  • Gideon Bachar,
  • Thomas Shpitzer,
  • Aviram Mizrachi

摘要

Objective

Research on age and prognosis for oral cavity squamous cell carcinomas (OSCCs) has shown inconsistent results. We aimed to establish age as an independent prognostic factor and determine an age cutoff for staging in OSCC.

Methods

Electronic records were reviewed for all OSCC patients treated between 2000 and 2020.

Results

The study involved 250 patients, identifying a mortality cutoff age of 65 through Receiver Operating Characteristic curve analysis (sensitivity 77%, specificity 49%). Patients ≥ 65 had lower survival rates for early-stage (TNM I-II; 63.5% vs. 96%, p < 0.001) and advanced-stage (TNM III-IV; 37.5% vs. 62%, p = 0.011) diseases. A proposed age-based TNM staging system categorized ≥ 65 as Stage III/IV, with comparable survival rates confirmed in a revised analysis.

Conclusion

The study identifies age, with a 65-year cutoff, as an independent prognostic factor in OSCC and highlights its role in improving current staging systems.

Level of evidence

III.