Introduction <p>In 2017, an innovative partnership was established between the ENT department of La Conception Hospital in Marseille and a city-hospital network (ILHUP) to facilitate early discharge after total laryngectomy (TL) and total pharyngo-laryngectomy (TPL). The main objective was to compare the home discharge rate versus transfer to a rehabilitation facility before and after implementation of this partnership.</p> Methods <p>This single-center retrospective study included 205 patients who underwent TL/TPL between January 2012 and December 2023, divided into two groups: group 1 (<i>n</i> = 93) and group 2 (<i>n</i> = 112) before and after implementation of the city-hospital network.</p> Results <p>The home discharge rate in Group 2 was significantly higher than in Group 1 (55.4% vs. 40.9%, <i>p</i> = 0.039). Within group 2, mean length of hospital stay (23.8 vs. 26.12 days, <i>p</i> = 0.295) and two-month readmission rate (4.8% vs. 10%, <i>p</i> = 0.321) were similar between patients discharged home and those transferred to rehabilitation facilities. Multivariate analysis showed that implementation of the city-hospital network partnership was the only factor independently associated with an increased home discharge rate (<i>p</i> = 0.018).</p> Conclusion <p>Implementation of a partnership with a city-hospital network significantly increased the home discharge rate after total (pharyngo-) laryngectomy without compromising patient safety.</p>