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Purpose <p>This study aims to analyze resectable T3–T4a glottic cancer patients treated with TOLM at a tertiary hospital, evaluating survival, function, and QoL in organ-preserved cases.</p> Methods <p>Patients with diagnosis of laryngeal glottic squamous cell carcinoma pT3–pT4a N &lt; 3 M0 treated with primary curative intention TOLM from 2005 to 2021 were included. Statistical analysis was performed, including survival rates. Quality of life was evaluated using VHI-10, EORTC-QLQ-C30 and EORTC-QLQ-HN43.</p> Results <p>82 patients were included in this study, predominantly male, with a mean age of 65.5&#xa0;years old. Laryngeal preservation rate was 76.83%. 5-year overall survival was 68.3%, 5-year Disease Specific Survival was 80.9%, 5-year Local disease-free survival was 91.2%. Medium VHI-10 score was 9.20 (SD ± 5.90), with nearly two thirds (63.33%) having a normal score. On the QLQ-C30 questionnaire, five of the six functional scales were over 80. On the QLQ-HN43 all the scales (single and multi-item) scored less than 16.</p> Conclusion <p>TOLM achieved comparable survival rates to radical surgery and other organ-preserving methods for locally advanced glottic cancer, as well as good functional outcomes with minimal post-surgical symptoms and mild voice impairment.</p>

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Balancing survival rates and quality-of-life outcomes after transoral laser microsurgery for locally advanced glottic cancer

  • 期刊论文

  • 发表日期：

    2025年4月4日

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  • Eduardo Breda,
  • Joana Marques,
  • Isabel Vasquez,
  • Eurico Monteiro

摘要

Purpose

This study aims to analyze resectable T3–T4a glottic cancer patients treated with TOLM at a tertiary hospital, evaluating survival, function, and QoL in organ-preserved cases.

Methods

Patients with diagnosis of laryngeal glottic squamous cell carcinoma pT3–pT4a N < 3 M0 treated with primary curative intention TOLM from 2005 to 2021 were included. Statistical analysis was performed, including survival rates. Quality of life was evaluated using VHI-10, EORTC-QLQ-C30 and EORTC-QLQ-HN43.

Results

82 patients were included in this study, predominantly male, with a mean age of 65.5 years old. Laryngeal preservation rate was 76.83%. 5-year overall survival was 68.3%, 5-year Disease Specific Survival was 80.9%, 5-year Local disease-free survival was 91.2%. Medium VHI-10 score was 9.20 (SD ± 5.90), with nearly two thirds (63.33%) having a normal score. On the QLQ-C30 questionnaire, five of the six functional scales were over 80. On the QLQ-HN43 all the scales (single and multi-item) scored less than 16.

Conclusion

TOLM achieved comparable survival rates to radical surgery and other organ-preserving methods for locally advanced glottic cancer, as well as good functional outcomes with minimal post-surgical symptoms and mild voice impairment.