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Purpose <p>The study aimed to evaluate the long-term efficacy and safety of superior laryngeal nerve (SLN) block for treating chronic neurogenic cough (CNC) in a large patient cohort.</p> Methods <p>A retrospective review was conducted on patients treated between January 2019 and October 2023. Data collected included patient demographics, number of injections, follow-up times, subjective cough severity, and Leicester Cough Questionnaire (LCQ) scores.</p> Results <p>Among 117 patients (76.1% female; mean age 66.1), the median number of injections was 3, with a median follow-up duration of 4 weeks. Subjective improvement was reported in 74.4% of cases, with mild adverse events occurring in 8.4% of injections. Regression analysis showed a strong correlation between decreased subjective severity and time. LCQ scores improved slightly within 1–3 months and 25–40 months.</p> Conclusion <p>The findings suggest that SLN blocks effectively reduce subjective severity and improve LCQ scores long-term, with sequential injections potentially reducing chronic steroid use risks. Further prospective studies are recommended to optimize dosing intervals.</p>

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Long-term efficacy of superior laryngeal nerve block for the treatment of chronic neurogenic cough

  • 期刊论文

  • 发表日期：

    2025年1月28日

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  • Tanner J. Diemer,
  • Brian A. Keith,
  • Shaun A. Nguyen,
  • Ashli K. O’Rourke

摘要

Purpose

The study aimed to evaluate the long-term efficacy and safety of superior laryngeal nerve (SLN) block for treating chronic neurogenic cough (CNC) in a large patient cohort.

Methods

A retrospective review was conducted on patients treated between January 2019 and October 2023. Data collected included patient demographics, number of injections, follow-up times, subjective cough severity, and Leicester Cough Questionnaire (LCQ) scores.

Results

Among 117 patients (76.1% female; mean age 66.1), the median number of injections was 3, with a median follow-up duration of 4 weeks. Subjective improvement was reported in 74.4% of cases, with mild adverse events occurring in 8.4% of injections. Regression analysis showed a strong correlation between decreased subjective severity and time. LCQ scores improved slightly within 1–3 months and 25–40 months.

Conclusion

The findings suggest that SLN blocks effectively reduce subjective severity and improve LCQ scores long-term, with sequential injections potentially reducing chronic steroid use risks. Further prospective studies are recommended to optimize dosing intervals.