Evaluating the relationship between obstructive sleep apnea and all-cause and cause-specific mortality in adults with and without metabolic syndrome using real-world data

Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder linked to increased risks of cardiovascular and metabolic disorders, significantly raising overall mortality rates. This study explores the associations between OSA and mortality in adults with and without Metabolic Syndrome (MetS) using data from the National Health and Nutrition Examination Survey (NHANES).

Data from NHANES (2005–2008) were analyzed, including 11,759 participants. OSA and MetS were identified based on survey responses and standard clinical criteria. Cox proportional hazards regression models were used to assess the relationship between OSA and mortality, adjusting for covariates. OSA was associated with significantly higher all-cause and cardiovascular mortality in the general population. In individuals without MetS, OSA was linked to higher all-cause and cardiovascular mortality. However, in individuals with MetS, OSA did not significantly affect mortality rates after adjusting for covariates.

OSA increases the risk of all-cause and cardiovascular mortality in individuals without MetS, emphasizing the need for early identification and management, particularly in those without metabolic comorbidities. In contrast, the impact of OSA on mortality in individuals with MetS may be mitigated by medical monitoring and treatment. These findings highlight the importance of individualized clinical strategies and call for further research to explore the underlying mechanisms of OSA-MetS interactions.