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Objectives <p>Ovarian stimulation (OS) and pregnancy were shown to be associated with a prothrombotic state. We sought to determine whether a positive pregnancy outcome is related to fibrin clot properties and thrombin generation in women with unexplained infertility (UI) after OS followed by intrauterine insemination (IUI).</p> Methods <p>We studied 70 women with UI, aged 30.7 ± 3.5&#xa0;years, BMI 24.7 ± kg/m<sup>2</sup> together with 70 controls who had healthy births matched for age and weight. We measured thrombin generation capacity, plasma fibrin clot permeability (K<sub>s</sub>), and fibrinolytic potential (clot lysis time, CLT). In women with UI, after OS followed by IUI, pregnancy outcomes were recorded.</p> Results <p>UI women had prolonged lag time (+ 10.0%) and lower thrombin generation reflected by ETP (−17.8%) and formed clots less permeable (− 20.8%; K<sub>s</sub>) and more resistant to lysis (+ 17.5% CLT) compared to controls (all <i>p</i> &lt; 0.05). Women with UI and positive pregnancy outcome (<i>n</i> = 19, 27.1%) showed increased K<sub>S</sub> (+ 67.9%) along with shorter CLT (− 15.9%) with no difference in thrombin generation, when compared to non-pregnant women. In women with UI ETP was associated with peak thrombin (<i>r</i> = 0.57, <i>p</i> = 0.02), whereas CLT was negatively correlated both with K<sub>S</sub> (<i>r</i> =  − 0.42, <i>p</i> = 0.001) and TSH (<i>r</i> =  − 0.56, <i>p</i> = 0.04).</p> Conclusions <p>Women with UI display unfavorably modified fibrin clot properties, especially those with negative pregnancy outcomes, which suggests the impact of fibrin clot characteristics on treatment results.</p>

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Unfavorably altered fibrin clot properties in women with unexplained infertility: association with pregnancy outcomes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月27日

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  • Magdalena Piróg,
  • Robert Jach,
  • Michał Ząbczyk,
  • Joanna Natorska

摘要

Objectives

Ovarian stimulation (OS) and pregnancy were shown to be associated with a prothrombotic state. We sought to determine whether a positive pregnancy outcome is related to fibrin clot properties and thrombin generation in women with unexplained infertility (UI) after OS followed by intrauterine insemination (IUI).

Methods

We studied 70 women with UI, aged 30.7 ± 3.5 years, BMI 24.7 ± kg/m2 together with 70 controls who had healthy births matched for age and weight. We measured thrombin generation capacity, plasma fibrin clot permeability (Ks), and fibrinolytic potential (clot lysis time, CLT). In women with UI, after OS followed by IUI, pregnancy outcomes were recorded.

Results

UI women had prolonged lag time (+ 10.0%) and lower thrombin generation reflected by ETP (−17.8%) and formed clots less permeable (− 20.8%; Ks) and more resistant to lysis (+ 17.5% CLT) compared to controls (all p < 0.05). Women with UI and positive pregnancy outcome (n = 19, 27.1%) showed increased KS (+ 67.9%) along with shorter CLT (− 15.9%) with no difference in thrombin generation, when compared to non-pregnant women. In women with UI ETP was associated with peak thrombin (r = 0.57, p = 0.02), whereas CLT was negatively correlated both with KS (r =  − 0.42, p = 0.001) and TSH (r =  − 0.56, p = 0.04).

Conclusions

Women with UI display unfavorably modified fibrin clot properties, especially those with negative pregnancy outcomes, which suggests the impact of fibrin clot characteristics on treatment results.