Background <p>Thin endometrium (TE) is a significant limiting factor for successful in vitro fertilization (IVF) and embryo transfer (ET), often resulting in poor pregnancy outcomes. Current therapeutic options remain limited and inconsistent in efficacy.</p> Objective <p>This review aims to comprehensively evaluate the clinical potential of platelet-rich plasma (PRP) therapy as an emerging treatment to improve endometrial thickness and fertility outcomes in patients with TE.</p> Methods <p>A systematic analysis of recent studies was conducted to summarize advancements in PRP application for TE. This includes evaluating PRP preparation techniques, treatment protocols, and reported clinical outcomes. Mechanistic insights into how PRP promotes endometrial regeneration through growth factors and angiogenesis were also explored.</p> Results <p>Evidence from current literature suggests that intrauterine infusion of PRP may enhance endometrial thickness and improve implantation and pregnancy rates in women with refractory TE. However, variations in PRP preparation methods and treatment protocols limit the comparability of results. Safety profiles appear favorable, with few reported adverse events.</p> Conclusion <p>PRP therapy holds promise as a regenerative approach for the treatment of TE. Nonetheless, the lack of standardized protocols and robust randomized controlled trials necessitates further research. Establishing consensus on preparation methods and treatment timing will be crucial for translating PRP therapy into routine clinical practice.</p>