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Purpose <p>To review how DNA methylation affects ovarian steroidogenesis in polycystic ovary syndrome (PCOS), with evidence from human and animal studies.</p> Recent findings <p>Women with PCOS show global DNA hypomethylation and altered methylation of ovarian steroidogenic genes, contributing to hyperandrogenism. Animal models of PCOS mirror these epigenetic changes and support a causal role, highlighting DNA methylation signatures as diagnostic biomarkers and therapeutic targets.</p>

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DNA methylation and its impact on ovarian steroidogenesis in women with polycystic ovary syndrome: insights from human and animal models

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月23日

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  • Yanyu Zhong,
  • Jin Ding,
  • Fei Xia

摘要

Purpose

To review how DNA methylation affects ovarian steroidogenesis in polycystic ovary syndrome (PCOS), with evidence from human and animal studies.

Recent findings

Women with PCOS show global DNA hypomethylation and altered methylation of ovarian steroidogenic genes, contributing to hyperandrogenism. Animal models of PCOS mirror these epigenetic changes and support a causal role, highlighting DNA methylation signatures as diagnostic biomarkers and therapeutic targets.