Reference charts for fetal corpus callosum length in the early second trimester: a prospective cross-sectional study

This study aimed to establish normal reference ranges for fetal corpus callosum (CC) measured by prenatal ultrasonography (USG) between 16 and 25 weeks of gestation in healthy fetuses.

A total of 809 fetuses in the second trimester were evaluated by transabdominal USG. All measurements were obtained by a single clinician.

Based on the correlation analysis, a significant positive correlation was found between gestational week and CC (r = 0.907, p < 0.001).

We anticipate that the reference intervals obtained from healthy fetuses will help clinicians who are interested in neurosonography to detect CC abnormalities at an early stage.