Scholarlink

<p>Psoriasis is an inflammatory skin condition that causes rapid proliferation of skin cells, leading to the formation of scales. By increasing the expression of the genes for interleukin-17A (<i>IL-17A</i>) and tumour necrosis factor alpha (TNF-α), interferon-kappa (<i>IFNK</i>) may be involved in the aetiology of psoriasis. This study aimed to evaluate <i>IFNK</i> and <i>IL-17A</i> gene expression levels in psoriatic cases and to explore their relationship with disease severity. The current case–control study included 150 subjects: 75 cases with chronic plaque psoriasis and 75 age- and gender-matched healthy controls. The severity of the disease was appraised using the Psoriasis Area and Severity Index (PASI) score. To determine <i>IFNK</i> and <i>IL-17A</i> mRNA expression levels, venous blood samples were obtained and subjected to quantitative real-time polymerase chain reaction (qRT-PCR). Significantly higher expression levels of <i>IFNK</i> and <i>IL-17A</i> were observed in cases compared to control subjects (<i>P</i> &lt; 0.001). Higher gene expression levels were observed in patients with severe psoriasis, with significant positive correlations between <i>IFNK</i> and PASI score (<i>r</i> = 0.947, <i>P</i> &lt; 0.001) and between <i>IL-17A</i> and PASI (<i>r</i> = 0.932, <i>P</i> &lt; 0.001). Indeed, a positive correlation was also observed between <i>IFNK</i> and <i>IL-17A</i> expression (<i>r</i> = 0.945, <i>P</i> &lt; 0.001). Psoriasis vulgaris is associated with significant elevation of <i>IFNK</i> and <i>IL-17A</i> gene expression. These markers may act as indicators of disease presence and severity, supporting their potential role as diagnostic and prognostic biomarkers in psoriasis vulgaris.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Interferon-kappa and interleukin-17 gene expression in psoriasis vulgaris: a case–control study

  • 期刊论文

  • 发表日期：

    2026年7月20日

查看全文
  • Wafaa Ahmed Shehata,
  • Mostafa Ahmed Hammam,
  • Sara A. El-Derbaly,
  • Azza Kamal Ibrahim,
  • Mai Medhat Mohamed Ghanem

摘要

Psoriasis is an inflammatory skin condition that causes rapid proliferation of skin cells, leading to the formation of scales. By increasing the expression of the genes for interleukin-17A (IL-17A) and tumour necrosis factor alpha (TNF-α), interferon-kappa (IFNK) may be involved in the aetiology of psoriasis. This study aimed to evaluate IFNK and IL-17A gene expression levels in psoriatic cases and to explore their relationship with disease severity. The current case–control study included 150 subjects: 75 cases with chronic plaque psoriasis and 75 age- and gender-matched healthy controls. The severity of the disease was appraised using the Psoriasis Area and Severity Index (PASI) score. To determine IFNK and IL-17A mRNA expression levels, venous blood samples were obtained and subjected to quantitative real-time polymerase chain reaction (qRT-PCR). Significantly higher expression levels of IFNK and IL-17A were observed in cases compared to control subjects (P < 0.001). Higher gene expression levels were observed in patients with severe psoriasis, with significant positive correlations between IFNK and PASI score (r = 0.947, P < 0.001) and between IL-17A and PASI (r = 0.932, P < 0.001). Indeed, a positive correlation was also observed between IFNK and IL-17A expression (r = 0.945, P < 0.001). Psoriasis vulgaris is associated with significant elevation of IFNK and IL-17A gene expression. These markers may act as indicators of disease presence and severity, supporting their potential role as diagnostic and prognostic biomarkers in psoriasis vulgaris.