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<p>Human immunodeficiency virus (HIV) is associated with a higher incidence of certain skin cancers and elevated mortality after a cancer diagnosis. However, studies inclusive of details on disease presentation and non-mortality clinical outcomes after a skin cancer diagnosis for people living with HIV (PWH) remain limited. We conducted a retrospective chart review of 56 melanoma patients (28 PWH and 28 people living without HIV [PWoH]) who received cancer care at Moffitt Cancer Center between 2004 and 2019, and 87 non-melanoma skin cancer (NMSC) patients (29 PWH, 29 PWoH, 29 OTR [organ transplant recipients]) who received cancer care at the University of South Florida between 2012 and 2020. Patient and clinical details, clinical outcomes after diagnosis, and HIV-associated data were described by cancer type. In the melanoma cohort, we observed a high mitotic index (≥ 2 mitoses per mm2) in 47% of PWH and 25% of PWoH (<i>p</i> = 0.18). Cox regression models adjusted for smoking and age revealed a non-significantly elevated mortality risk among PWH diagnosed with melanoma compared to PWoH (HR 2.3, CI 0.8–6.8, <i>p</i> = 0.15). In the NMSC cohort, we observed that a greater proportion of NMSC patients were diagnosed with squamous cell carcinoma (SCC) in PWH compared to PWoH (38% vs. 21%, <i>p</i> = 0.03). When combining the PWH and OTR into a single immunosuppressed study group, these NMSC patients experienced a non-significantly elevated mortality risk compared to PWoH (HR 4.73, CI 0.61–36.8, <i>p</i> = 0.14). While our findings were not statistically significant given the limited sample size, our data provide preliminary evidence of potential variability in tumor aggressiveness and clinical outcomes for PWH diagnosed with skin cancer.&#xa0;</p>

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Clinical characteristics and outcomes of melanoma and non-melanoma skin cancers in persons living with HIV

  • 期刊论文

  • 发表日期：

    2026年7月29日

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  • Grace Wei,
  • Nathan Van Bibber,
  • Kristina Bowles,
  • Sweta Sinha,
  • Kerry Hennessy,
  • Basil Cherpelis,
  • Anna E. Coghill

摘要

Human immunodeficiency virus (HIV) is associated with a higher incidence of certain skin cancers and elevated mortality after a cancer diagnosis. However, studies inclusive of details on disease presentation and non-mortality clinical outcomes after a skin cancer diagnosis for people living with HIV (PWH) remain limited. We conducted a retrospective chart review of 56 melanoma patients (28 PWH and 28 people living without HIV [PWoH]) who received cancer care at Moffitt Cancer Center between 2004 and 2019, and 87 non-melanoma skin cancer (NMSC) patients (29 PWH, 29 PWoH, 29 OTR [organ transplant recipients]) who received cancer care at the University of South Florida between 2012 and 2020. Patient and clinical details, clinical outcomes after diagnosis, and HIV-associated data were described by cancer type. In the melanoma cohort, we observed a high mitotic index (≥ 2 mitoses per mm2) in 47% of PWH and 25% of PWoH (p = 0.18). Cox regression models adjusted for smoking and age revealed a non-significantly elevated mortality risk among PWH diagnosed with melanoma compared to PWoH (HR 2.3, CI 0.8–6.8, p = 0.15). In the NMSC cohort, we observed that a greater proportion of NMSC patients were diagnosed with squamous cell carcinoma (SCC) in PWH compared to PWoH (38% vs. 21%, p = 0.03). When combining the PWH and OTR into a single immunosuppressed study group, these NMSC patients experienced a non-significantly elevated mortality risk compared to PWoH (HR 4.73, CI 0.61–36.8, p = 0.14). While our findings were not statistically significant given the limited sample size, our data provide preliminary evidence of potential variability in tumor aggressiveness and clinical outcomes for PWH diagnosed with skin cancer.