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<p>Pemphigus vulgaris (PV) is a rare autoimmune bullous disease whose prevalence varies by geography and ethnicity. Studies have shown that ST18 polymorphisms, such as rs2304365 and rs17315309, are associated with PV in different populations. In this study, we evaluated the prevalence of the rs17315309 single-nucleotide polymorphism (SNP) in 35 PV patients and 40 healthy individuals without a family history of PV. Despite previous studies involving Iraqi and Jewish populations, this study did not find an association between the risk allele and the disease. Large-scale cohort studies with long-term follow-up are warranted to identify the ethnic and geographic distribution of polymorphisms associated with PV and demonstrate their impact on the disease.</p>

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ST18 single nucleotide polymorphism in pemphigus vulgaris: single center study from Turkey

  • 期刊论文

  • 发表日期：

    2026年6月29日

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  • Meryem Aktas,
  • Ebru Arslan,
  • Pinar Ata,
  • Mahsan Azimi,
  • Zuleyha Ozgen,
  • Deniz Yucelten

摘要

Pemphigus vulgaris (PV) is a rare autoimmune bullous disease whose prevalence varies by geography and ethnicity. Studies have shown that ST18 polymorphisms, such as rs2304365 and rs17315309, are associated with PV in different populations. In this study, we evaluated the prevalence of the rs17315309 single-nucleotide polymorphism (SNP) in 35 PV patients and 40 healthy individuals without a family history of PV. Despite previous studies involving Iraqi and Jewish populations, this study did not find an association between the risk allele and the disease. Large-scale cohort studies with long-term follow-up are warranted to identify the ethnic and geographic distribution of polymorphisms associated with PV and demonstrate their impact on the disease.