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<p>Neutrophil gelatinase-associated lipocalin, also called lipocalin-2 (LCN2), is recently discovered adipokine that has been shown to play crucial role in various inflammatory processes. It is involved in cell apoptosis, damage, progression of cancers and shows bacteriostatic effect. Serum concentration of LCN2 is elevated in patients with obesity, diabetes and metabolic syndrome. The aim of this systematic review was to investigate the role of serum LCN2 in the course of hidradenitis suppurativa, atopic dermatitis, allergic contact dermatitis, chronic urticaria, chronic leg ulcers and bullous pemphigoid, as well as its association with cardiovascular risk factors. MEDLINE and EMBASE databases were searched for studies published until December 2024 according to the PRISMA guidelines, supplemented by manual research of PubMed database. 20 studies meeting the predefined criteria were enrolled into the final analysis. Patients with hidradenitis suppurativa exhibited elevated LCN2 levels, strongly correlating with disease severity. In atopic dermatitis, LCN2 findings were inconsistent, showing both increases and decreases without a definitive link to severity or pruritus. Allergic contact dermatitis showed elevated LCN2, especially post-allergen exposure. Chronic urticaria involved increased LCN2, inversely associated with disease activity. In chronic venous leg ulcers, LCN2 was elevated in plasma and wound fluid, with levels declining during healing. LCN2 is a significant biomarker in dermatological conditions and is closely associated with cardiovascular risk via systemic inflammation. LCN2’s connection to cardiometabolic indicators suggests a mechanistic link between cutaneous and cardiovascular diseases. Standardized methodologies are essential to optimize its clinical utility in managing inflammatory dermatoses and related cardiovascular outcomes.</p>

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Serum lipocalin-2 in selected dermatoses: implications for systemic inflammation and cardiometabolic risk

  • 期刊论文

  • 发表日期：

    2026年5月22日

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  • Frątczak Aleksandra,
  • Polak Karina,
  • Majewski Michał,
  • Łanocha Mikołaj,
  • Muszyński Tomasz,
  • Kruczek Wiktor,
  • Miziołek Bartosz,
  • Bergler-Czop Beata

摘要

Neutrophil gelatinase-associated lipocalin, also called lipocalin-2 (LCN2), is recently discovered adipokine that has been shown to play crucial role in various inflammatory processes. It is involved in cell apoptosis, damage, progression of cancers and shows bacteriostatic effect. Serum concentration of LCN2 is elevated in patients with obesity, diabetes and metabolic syndrome. The aim of this systematic review was to investigate the role of serum LCN2 in the course of hidradenitis suppurativa, atopic dermatitis, allergic contact dermatitis, chronic urticaria, chronic leg ulcers and bullous pemphigoid, as well as its association with cardiovascular risk factors. MEDLINE and EMBASE databases were searched for studies published until December 2024 according to the PRISMA guidelines, supplemented by manual research of PubMed database. 20 studies meeting the predefined criteria were enrolled into the final analysis. Patients with hidradenitis suppurativa exhibited elevated LCN2 levels, strongly correlating with disease severity. In atopic dermatitis, LCN2 findings were inconsistent, showing both increases and decreases without a definitive link to severity or pruritus. Allergic contact dermatitis showed elevated LCN2, especially post-allergen exposure. Chronic urticaria involved increased LCN2, inversely associated with disease activity. In chronic venous leg ulcers, LCN2 was elevated in plasma and wound fluid, with levels declining during healing. LCN2 is a significant biomarker in dermatological conditions and is closely associated with cardiovascular risk via systemic inflammation. LCN2’s connection to cardiometabolic indicators suggests a mechanistic link between cutaneous and cardiovascular diseases. Standardized methodologies are essential to optimize its clinical utility in managing inflammatory dermatoses and related cardiovascular outcomes.