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<p>The exact etiopathogenesis of rosacea remains unclear, although various factors have been implicated, including oxidative stress. Dietary total antioxidant capacity (DTAC) reflects the cumulative antioxidant potential of consumed foods and may influence systemic oxidative stress. The aim of this study is to investigate dietary antioxidant capacity and systemic oxidative stress parameters in patients with rosacea. This prospective, single-center, case-control study included 51 rosacea patients and 46 healthy controls. DTAC values were significantly lower in the rosacea group than in the controls (6.95 ± 1.98 versus 11.55 ± 4.77; <i>p</i> &lt; 0.001). Serum levels of total antioxidant capacity (TAC) were significantly lower in the rosacea patients than in the controls (<i>p</i> &lt; 0.001), while serum total oxidant capacity (TOC) and oxidative stress index (OSI) values were significantly higher in the rosacea patients (<i>p</i> &lt; 0.001, for both). Serum TOC and OSI levels were significantly higher in papulopustular rosacea patients than in erythematotelangiectatic rosacea patients (<i>p</i> = 0.001, <i>p</i> = 0.011, respectively). The small sample size, the cross-sectional design, and the relatively short dietary recall period represent limitations of the study. A diet rich in antioxidants may be beneficial in the treatment of rosacea by decreasing oxidative stress.</p>

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Evaluation of dietary antioxidant capacity and systemic oxidative stress in patients with rosacea: a case-control study

  • 期刊论文

  • 发表日期：

    2026年1月7日

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  • Ezgi Aktaş,
  • Ayşe Elif Tapkı,
  • Şeyma Gürbüz,
  • Yavuz Semiz

摘要

The exact etiopathogenesis of rosacea remains unclear, although various factors have been implicated, including oxidative stress. Dietary total antioxidant capacity (DTAC) reflects the cumulative antioxidant potential of consumed foods and may influence systemic oxidative stress. The aim of this study is to investigate dietary antioxidant capacity and systemic oxidative stress parameters in patients with rosacea. This prospective, single-center, case-control study included 51 rosacea patients and 46 healthy controls. DTAC values were significantly lower in the rosacea group than in the controls (6.95 ± 1.98 versus 11.55 ± 4.77; p < 0.001). Serum levels of total antioxidant capacity (TAC) were significantly lower in the rosacea patients than in the controls (p < 0.001), while serum total oxidant capacity (TOC) and oxidative stress index (OSI) values were significantly higher in the rosacea patients (p < 0.001, for both). Serum TOC and OSI levels were significantly higher in papulopustular rosacea patients than in erythematotelangiectatic rosacea patients (p = 0.001, p = 0.011, respectively). The small sample size, the cross-sectional design, and the relatively short dietary recall period represent limitations of the study. A diet rich in antioxidants may be beneficial in the treatment of rosacea by decreasing oxidative stress.