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Background <p>Acne vulgaris is a chronic, inflammatory disease of the pilosebaceous unit. This study aimed to investigate serum inflammatory markers in acne patients and compare the anti-inflammatory effects of systemic isotretinoin and doxycycline by evaluating their effects on these markers.</p> Medhods <p>This study was designed as a retrospective study. 100 patients with moderate to severe acne vulgaris were treated with either doxycycline (100&#xa0;mg/day) or isotretinoin (0.5–1&#xa0;mg/kg/day) and compared with 50 age- and sex-matched healthy controls. Serum inflammatory markers, including Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregated Systemic Inflammation Index (AISI), Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratio (PLR), and Monocyte/HDL Ratio (MHR), were measured at baseline and during treatment.</p> Results <p>No significant baseline difference was found between groups. In the doxycycline group, SII, SIRI, and AISI levels significantly decreased at 2 months. In the isotretinoin group, no significant within-group changes were observed. Between-group comparisons revealed lower inflammatory marker values in the doxycycline group at 2 months.</p> Conclusion <p>Doxycycline treatment led to significant short-term reductions in serum inflammatory markers, suggesting more rapid anti-inflammatory effects than isotretinoin. These findings highlight the potential utility of these indices in monitoring treatment response.</p>

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Evaluation of serum inflammatory markers in acne patients treated with systemic isotretinoin or doxycycline

  • 期刊论文

  • 发表日期：

    2025年12月15日

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  • Nilufer Ertem Gunegul,
  • Ozge Mine Orenay,
  • Nermin Karaosmanoglu

摘要

Background

Acne vulgaris is a chronic, inflammatory disease of the pilosebaceous unit. This study aimed to investigate serum inflammatory markers in acne patients and compare the anti-inflammatory effects of systemic isotretinoin and doxycycline by evaluating their effects on these markers.

Medhods

This study was designed as a retrospective study. 100 patients with moderate to severe acne vulgaris were treated with either doxycycline (100 mg/day) or isotretinoin (0.5–1 mg/kg/day) and compared with 50 age- and sex-matched healthy controls. Serum inflammatory markers, including Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregated Systemic Inflammation Index (AISI), Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratio (PLR), and Monocyte/HDL Ratio (MHR), were measured at baseline and during treatment.

Results

No significant baseline difference was found between groups. In the doxycycline group, SII, SIRI, and AISI levels significantly decreased at 2 months. In the isotretinoin group, no significant within-group changes were observed. Between-group comparisons revealed lower inflammatory marker values in the doxycycline group at 2 months.

Conclusion

Doxycycline treatment led to significant short-term reductions in serum inflammatory markers, suggesting more rapid anti-inflammatory effects than isotretinoin. These findings highlight the potential utility of these indices in monitoring treatment response.