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<p>Keratinocyte carcinoma mainly affect patients over 60 years of age. However, early-onset KC (eoKC) is an important subject, as it may contribute to an increased future burden of skin cancer and may be linked to other early-onset malignancies. This study examines whether early-onset keratinocyte carcinoma (eoKC, &lt; 40 years) is associated with other primary cancers before age 50. Using Danish national registries, we studied 1,263,544 individuals born 1960–1972, followed from age 20–50. Individuals diagnosed with basal cell or squamous cell carcinoma before age 40 were classified as eoKC. We analyzed the incidence of subsequent non-melanoma skin cancer (NMSC) and other cancers before age 50, comparing eoKC patients with a control group. Among the cohort, 3,471 individuals had eoKC (incidence: 14.5 per 100,000 person-years). Most developed only one NMSC before age 50. Patients with eoKC had a significantly higher risk of other primary cancers before age 50 (HR 2.60, 95% CI: 2.34–2.90), higher in males (HR 3.14) than females (HR 2.17). eoKC is associated with a significantly increased risk of cancer before age 50. These findings support informing eoKC patients and clinicians about this risk and considering enhanced surveillance and genetic counseling.</p>

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Early-onset keratinocyte carcinoma and risk of other malignancy before age 50: a nationwide cohort study

  • 期刊论文

  • 发表日期：

    2025年12月5日

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  • Anne Sofie Krogh Holdam,
  • Vibeke Koudahl,
  • Hans B. Rahr,
  • Erik Frostberg,
  • Karina Rønlund

摘要

Keratinocyte carcinoma mainly affect patients over 60 years of age. However, early-onset KC (eoKC) is an important subject, as it may contribute to an increased future burden of skin cancer and may be linked to other early-onset malignancies. This study examines whether early-onset keratinocyte carcinoma (eoKC, < 40 years) is associated with other primary cancers before age 50. Using Danish national registries, we studied 1,263,544 individuals born 1960–1972, followed from age 20–50. Individuals diagnosed with basal cell or squamous cell carcinoma before age 40 were classified as eoKC. We analyzed the incidence of subsequent non-melanoma skin cancer (NMSC) and other cancers before age 50, comparing eoKC patients with a control group. Among the cohort, 3,471 individuals had eoKC (incidence: 14.5 per 100,000 person-years). Most developed only one NMSC before age 50. Patients with eoKC had a significantly higher risk of other primary cancers before age 50 (HR 2.60, 95% CI: 2.34–2.90), higher in males (HR 3.14) than females (HR 2.17). eoKC is associated with a significantly increased risk of cancer before age 50. These findings support informing eoKC patients and clinicians about this risk and considering enhanced surveillance and genetic counseling.