Scholarlink

<p>Hair loss is a prevalent disorder negatively affecting the quality of life and mental health. However, current treatment options are limited, highlighting the urgent need for the development of new therapies. Growing evidence has proven that stem cell-derived nutrient medium and exosome are novel approaches to future hair loss therapy. Limelight (CB-EVs) is an umbilical cord blood-derived exosome product. This study was to investigate the safety and efficacy of Limelight (CB-EVs) for hair growth ex vivo. Our analysis revealed that concentrations of Limelight (CB-EVs) below 5 U/ml demonstrated no cytotoxicity in vitro through MTS assay. In hair follicle culture, concentrations of 0.1, 0.01, and 0.001 U/ml significantly promoted hair elongation while maintaining hair bulb diameter. Analysis of the hair growth cycle indicated a reduced transition from the anagen phase to the catagen phase. Overexpression of Laminin V and Collagen XVII were seen by immunohistochemistry staining. These results endorse the exosome product, Limelight (CB-EVs), offers a safe and effective method for stimulating hair growth ex vivo.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII: an ex vivo study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月29日

查看全文
  • Caijun Jin,
  • Hye-Won Park,
  • Yongxun Jin,
  • Xinrui Zhang,
  • Pham Ngoc Chien,
  • Thuy-Tien Thi Trinh,
  • Nguyen Ngan Giang,
  • Linh Thi Thuy Le,
  • Teak-In Oh,
  • Lee Yong-Hyun,
  • Seungchan Kim,
  • Chan-Yeong Heo

摘要

Hair loss is a prevalent disorder negatively affecting the quality of life and mental health. However, current treatment options are limited, highlighting the urgent need for the development of new therapies. Growing evidence has proven that stem cell-derived nutrient medium and exosome are novel approaches to future hair loss therapy. Limelight (CB-EVs) is an umbilical cord blood-derived exosome product. This study was to investigate the safety and efficacy of Limelight (CB-EVs) for hair growth ex vivo. Our analysis revealed that concentrations of Limelight (CB-EVs) below 5 U/ml demonstrated no cytotoxicity in vitro through MTS assay. In hair follicle culture, concentrations of 0.1, 0.01, and 0.001 U/ml significantly promoted hair elongation while maintaining hair bulb diameter. Analysis of the hair growth cycle indicated a reduced transition from the anagen phase to the catagen phase. Overexpression of Laminin V and Collagen XVII were seen by immunohistochemistry staining. These results endorse the exosome product, Limelight (CB-EVs), offers a safe and effective method for stimulating hair growth ex vivo.