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<p>Prurigo nodularis (PN) is a chronic pruritic condition that may share immunological features with atopic diseases. While cross-sectional studies suggest an association, longitudinal evidence on the risk of developing atopic diseases after PN diagnosis is limited. This population-based retrospective cohort study based on the TriNetX research network aimed to investigate the relationship between PN and the subsequent risk of atopic diseases—atopic dermatitis (AD), asthma, allergic rhinitis (AR), and conjunctivitis. PN patients and matched controls (16,005 each) were followed for up to 15 years. Propensity score matching accounted for demographic, socioeconomic, and medical factors. Hazard ratios (HR) and 95% confidence intervals (CI) were used to evaluate the risk of incident atopic diseases. Sensitivity analyses addressed methodological biases. PN patients had significantly higher risks of atopic diseases, particularly AD (HR: 5.52; 95% CI: 4.39–6.94), followed by asthma (HR: 1.51; 95% CI: 1.35–1.68), conjunctivitis (HR: 1.28; 95% CI: 1.12–1.47), and AR (HR: 1.18; 95% CI: 1.08–1.29). Risks were especially elevated in males and older adults, with AD risk highest in those aged ≥ 65 years (HR: 7.99; 95% CI: 5.21–12.26). As a conclusion, we report that PN significantly increases the risk of developing atopic diseases, especially AD. These findings support the need for increased awareness of atopic diseases among PN patients, particularly older adults and males, to improve patient outcomes through integrated care.</p>

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New-onset atopic diseases in people with prurigo nodularis: a multi-center retrospective cohort study of electronic medical records

  • 期刊论文

  • 发表日期：

    2025年10月11日

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  • Hui-Chin Chang,
  • Shao-Wei Lo,
  • Hsin-Yo Lu,
  • Yung-Fang Tu,
  • Christine Hsu,
  • Chih-Lung Wu,
  • Meng-Che Wu,
  • Shuo-Yan Gau

摘要

Prurigo nodularis (PN) is a chronic pruritic condition that may share immunological features with atopic diseases. While cross-sectional studies suggest an association, longitudinal evidence on the risk of developing atopic diseases after PN diagnosis is limited. This population-based retrospective cohort study based on the TriNetX research network aimed to investigate the relationship between PN and the subsequent risk of atopic diseases—atopic dermatitis (AD), asthma, allergic rhinitis (AR), and conjunctivitis. PN patients and matched controls (16,005 each) were followed for up to 15 years. Propensity score matching accounted for demographic, socioeconomic, and medical factors. Hazard ratios (HR) and 95% confidence intervals (CI) were used to evaluate the risk of incident atopic diseases. Sensitivity analyses addressed methodological biases. PN patients had significantly higher risks of atopic diseases, particularly AD (HR: 5.52; 95% CI: 4.39–6.94), followed by asthma (HR: 1.51; 95% CI: 1.35–1.68), conjunctivitis (HR: 1.28; 95% CI: 1.12–1.47), and AR (HR: 1.18; 95% CI: 1.08–1.29). Risks were especially elevated in males and older adults, with AD risk highest in those aged ≥ 65 years (HR: 7.99; 95% CI: 5.21–12.26). As a conclusion, we report that PN significantly increases the risk of developing atopic diseases, especially AD. These findings support the need for increased awareness of atopic diseases among PN patients, particularly older adults and males, to improve patient outcomes through integrated care.