Scholarlink

<p>Keloids are a skin fibrotic disease marked by extracellular matrix(ECM) deposition due to excessive fibroblast proliferation, yet the precise mechanism of their formation remains unclear. Consequently, treating keloids clinically proves to be very challenging. Lately, ferroptosis has been implicated in the etiopathogenesis of a variety of fibrotic diseases. Thus, induction of ferroptosis in keloid fibroblasts (KFs) has potential clinical significance in the treatment of keloids. As an inhibitor of glutathione peroxidase 4 (GPX4), RSL3 could bind to GPX4, and suppress GPX4 activity and trigger cells ferroptosis which maybe a novel approach for treating hyperproliferative diseases. Therefore, assessing the impact of RSL3 on keloid disease is currently very necessary. In our studies, we verified that RSL3 can inhibit the gene and protein expression of GPX4 in primary KFs, suppress the proliferation and migration of primary KFs, and reduce the formation of collagen in KFs. Furthermore, we provide the proof that RSL3 induces stagnation of KF migration and inhibits angiogenesis. Our findings suggest that RSL3 deserves systematic investigation as a potential therapeutic method for keloids.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

RSL3 inhibits keloid fibroblasts proliferation and migration by downregulation of glutathione peroxidase 4

  • 期刊论文

  • 发表日期：

    2025年8月20日

查看全文
  • Jingyan Huang,
  • Zhen Gao,
  • Hongkun Zheng,
  • Shun Yu,
  • Fei Liu,
  • Xusong Luo,
  • Xiuxia Wang,
  • Jun Yang

摘要

Keloids are a skin fibrotic disease marked by extracellular matrix(ECM) deposition due to excessive fibroblast proliferation, yet the precise mechanism of their formation remains unclear. Consequently, treating keloids clinically proves to be very challenging. Lately, ferroptosis has been implicated in the etiopathogenesis of a variety of fibrotic diseases. Thus, induction of ferroptosis in keloid fibroblasts (KFs) has potential clinical significance in the treatment of keloids. As an inhibitor of glutathione peroxidase 4 (GPX4), RSL3 could bind to GPX4, and suppress GPX4 activity and trigger cells ferroptosis which maybe a novel approach for treating hyperproliferative diseases. Therefore, assessing the impact of RSL3 on keloid disease is currently very necessary. In our studies, we verified that RSL3 can inhibit the gene and protein expression of GPX4 in primary KFs, suppress the proliferation and migration of primary KFs, and reduce the formation of collagen in KFs. Furthermore, we provide the proof that RSL3 induces stagnation of KF migration and inhibits angiogenesis. Our findings suggest that RSL3 deserves systematic investigation as a potential therapeutic method for keloids.