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<p>Striae distensae [SD], often referred to as stretch marks, are common linear lesions seen in individuals of all ages. Many treatment choices are available, however, not yet satisfactory. Amniotic fluid contains many growth factors which can be helpful in treatment of stretch marks. This work aimed to assess the efficacy and safety of irradiated amniotic collagen matrix (IACM) with micro-needling in treatment of stretch marks. This was a prospective, right-left comparative study carried out on 40 patients presenting with striae. Every patient received six sessions every 2&#xa0;weeks, for the right side, micro-needling associated with application of IACM was used, for the left side micro-needling only was used. The patients were followed up for 3 months. Skin biopsies were taken before and after treatment, stained with Masson trichrome and Orcein stains to confirm clinical response. In both sides, there was significant improvement after treatment and there was significant difference with better results in the right side than the left side as regarding the degree of improvement, percentage of improvement and start of response. This method is safe, effective, and good tolerated office techniques with minimal side effects for treatment of stretch marks.</p>

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Microneedling using irradiated amniotic collagen matrix versus microneedling alone in the treatment of stretch marks

  • 期刊论文

  • 发表日期：

    2025年7月31日

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  • Nashwa K. Radwan,
  • Samah S. Ghanem,
  • Ghada F. R. Hassan,
  • Samia O. Nassar

摘要

Striae distensae [SD], often referred to as stretch marks, are common linear lesions seen in individuals of all ages. Many treatment choices are available, however, not yet satisfactory. Amniotic fluid contains many growth factors which can be helpful in treatment of stretch marks. This work aimed to assess the efficacy and safety of irradiated amniotic collagen matrix (IACM) with micro-needling in treatment of stretch marks. This was a prospective, right-left comparative study carried out on 40 patients presenting with striae. Every patient received six sessions every 2 weeks, for the right side, micro-needling associated with application of IACM was used, for the left side micro-needling only was used. The patients were followed up for 3 months. Skin biopsies were taken before and after treatment, stained with Masson trichrome and Orcein stains to confirm clinical response. In both sides, there was significant improvement after treatment and there was significant difference with better results in the right side than the left side as regarding the degree of improvement, percentage of improvement and start of response. This method is safe, effective, and good tolerated office techniques with minimal side effects for treatment of stretch marks.