<p>Seborrheic dermatitis is a common inflammatory skin disease that primarily affects the scalp, face, and body folds. Recent studies have shown that seborrheic dermatitis may be associated with inflammation and cardiometabolic conditions. We aimed to investigate this relationship in our study. Fifty patients with seborrheic dermatitis who came to the dermatology outpatient clinic and completely healthy patients in a similar age group were included in the study. Echocardiographic findings and heart rates of the patient and control groups were recorded on previously prepared forms. The mean epicardial fat tissue thickness of the patient group was 0.72 ± 0.04, while the mean of the control group was 0.62 ± 0.05, and this difference was considered significant (<i>P</i> &lt; 0.001). There was no significant difference between the patient and control groups in terms of left atrium (<i>p</i> = 0.759), interventricular septum thickness (<i>p</i> = 0.252), and heart rate (<i>p</i> = 0.835). Epicardial fat tissue loses its protective role in pathological processes and plays a role in cardiovascular diseases, especially coronary artery disease, in inflammatory processes. In this respect, SD patients should be carefully monitored for long-term, especially for coronary artery disease.</p>