<p>Random skin flap transplantation is critical in wound repair, organ reconstruction and cosmetic surgery, yet skin flap necrosis remains a common and challenging issue. Quercetin, a flavonoid abundant in various plants, exhibits anti-inflammatory, antioxidant, and other beneficial pharmacological effects. Recent studies suggest quercetin can improve random skin flap survival by modulating inflammation, reducing oxidative stress, and promoting angiogenesis. This review evaluates quercetin’s potential mechanisms and efficacy, proposing a foundation for its clinical use in preventing ischemic necrosis and enhancing flap viability.</p>

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Research progress on quercetin in improving the survival rate of random skin flap

  • Siping Xu,
  • Wenhua Zhang,
  • Xuanfen Zhang

摘要

Random skin flap transplantation is critical in wound repair, organ reconstruction and cosmetic surgery, yet skin flap necrosis remains a common and challenging issue. Quercetin, a flavonoid abundant in various plants, exhibits anti-inflammatory, antioxidant, and other beneficial pharmacological effects. Recent studies suggest quercetin can improve random skin flap survival by modulating inflammation, reducing oxidative stress, and promoting angiogenesis. This review evaluates quercetin’s potential mechanisms and efficacy, proposing a foundation for its clinical use in preventing ischemic necrosis and enhancing flap viability.