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Introduction <p>The use of a 36-mm femoral head in primary total hip replacement (THR) increases the jump distance and offers a wider impingement-free range of motion, theoretically reducing the risk of post-operative dislocation. However, concerns exist regarding its potentially greater impact on polyethylene wear and associated risks of liner fracture, aseptic loosening, and head-neck taper corrosion, compared to 32-mm femoral heads. This meta-analysis aims to compare the risk of revision for dislocation and all-causes when using 36-mm versus 32-mm metal or ceramic femoral heads with polyethylene liners for primary THR.</p> Methods <p>Medline, Embase, Web of Science, and the Cochrane Library were searched for relevant studies, while annual reports of arthroplasty registries were searched for relevant data. Random effects meta-analysis was performed. Sensitivity analysis was conducted, limiting to THR performed for osteoarthritis and using cross-linked polyethylene liners, or statistically adjusting for this factor. The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO ID CRD42024557895).</p> Results <p>Four observational studies and two registry reports were identified. Median follow-up ranged from 2.1 to 4.7 years (inter-quartile range values spanned from 0.9 to 7.7 years). The main analyses demonstrated that 36-mm heads were associated with a marginal reduction in the risk of revision for dislocation (HR 0.85, 95%CI 0.72–1.01, <i>p</i> = 0.058; <i>n</i> = 241,136) without an increased risk of all-cause revision (HR 1.06, 95%CI 0.95–1.18, <i>p</i> = 0.287; <i>n</i> = 942,617). Similar results were observed in the sensitivity analyses.</p> Discussion <p>At early to midterm follow-up, the use of 36-mm heads were not associated with an increased risk of revision for all-causes, compared to 32-mm heads. However, they may offer a protective reduction against revision for dislocation, as a marginal statistically significant reduction was observed, indicating a possible benefit. Further studies investigating these outcomes at longer-term follow up are needed to understand whether these revision risk profiles are maintained.</p>

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Revision for dislocation and all-causes following primary total hip replacement using 36-mm versus 32-mm femoral heads on polyethylene liners: a systematic review and meta-analysis

  • 期刊论文

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  • 发表日期：

    2025年12月15日

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  • Muhamed M. Farhan-Alanie,
  • Mina Abdul-Hussein,
  • Daniel Gallacher,
  • Prakrit R. Kumar,
  • Rajpreet Sahemey,
  • Peter D. H. Wall,
  • Michael Blankstein

摘要

Introduction

The use of a 36-mm femoral head in primary total hip replacement (THR) increases the jump distance and offers a wider impingement-free range of motion, theoretically reducing the risk of post-operative dislocation. However, concerns exist regarding its potentially greater impact on polyethylene wear and associated risks of liner fracture, aseptic loosening, and head-neck taper corrosion, compared to 32-mm femoral heads. This meta-analysis aims to compare the risk of revision for dislocation and all-causes when using 36-mm versus 32-mm metal or ceramic femoral heads with polyethylene liners for primary THR.

Methods

Medline, Embase, Web of Science, and the Cochrane Library were searched for relevant studies, while annual reports of arthroplasty registries were searched for relevant data. Random effects meta-analysis was performed. Sensitivity analysis was conducted, limiting to THR performed for osteoarthritis and using cross-linked polyethylene liners, or statistically adjusting for this factor. The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO ID CRD42024557895).

Results

Four observational studies and two registry reports were identified. Median follow-up ranged from 2.1 to 4.7 years (inter-quartile range values spanned from 0.9 to 7.7 years). The main analyses demonstrated that 36-mm heads were associated with a marginal reduction in the risk of revision for dislocation (HR 0.85, 95%CI 0.72–1.01, p = 0.058; n = 241,136) without an increased risk of all-cause revision (HR 1.06, 95%CI 0.95–1.18, p = 0.287; n = 942,617). Similar results were observed in the sensitivity analyses.

Discussion

At early to midterm follow-up, the use of 36-mm heads were not associated with an increased risk of revision for all-causes, compared to 32-mm heads. However, they may offer a protective reduction against revision for dislocation, as a marginal statistically significant reduction was observed, indicating a possible benefit. Further studies investigating these outcomes at longer-term follow up are needed to understand whether these revision risk profiles are maintained.