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High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年7月25日

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  • Marius Schwabenland,
  • Dilara Hasavci,
  • Sibylle Frase,
  • Katharina Wolf,
  • Nikolaus Deigendesch,
  • Joerg M. Buescher,
  • Kirsten D. Mertz,
  • Benjamin Ondruschka,
  • Hermann Altmeppen,
  • Jakob Matschke,
  • Markus Glatzel,
  • Stephan Frank,
  • Robert Thimme,
  • Juergen Beck,
  • Jonas A. Hosp,
  • Thomas Blank,
  • Bertram Bengsch,
  • Marco Prinz

摘要

The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119+P2RY12+CD68+Iba1+HLA-DR+CD11c+SCAMP2+ microglia assembled in prototypical cellular nodules. In contrast to acute SARS-CoV-2 cases, the frequency of CD8+ parenchymal T cells was reduced, suggesting an immune shift toward innate immune activation that may contribute to neurological alterations in post-COVID-19 patients.