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<p>Protein and polypeptides drugs require frequent administration due to low bioavailability and poor stability, leading to reduced patient compliance. We developed a nano-delivery system for the efficient delivery of bovine serum albumin (BSA) based on carboxymethyl-β-cyclodextrin (CM-β-CD) and polyethylene glycol-grafted chitosan (CS-g-mPEG) via polyelectrolyte complexation method. The effects of factors such as volume ratio, pH and grafting degree on particle size, stability, and drug release behavior were investigated. Under optimal conditions, the size of nanoparticle was 223&#xa0;nm with polydispersity index of 0.131, and the Zeta potential was + 23.86 mV. In vitro release studies demonstrated the nanoparticles can achieve pH-responsive drug release, with release rate of 74.3% in simulated intestinal fluid (pH = 6.8), following the Ritger-Peppas model. Moreover, this nano drug carrier exhibits excellent biocompatibility and long-circulation performance, providing a novel strategy with potential applications for protein drug delivery.</p>

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Cyclodextrin-based pH-responsive and long-circulating nanoparticles for efficient delivery of protein

  • 期刊论文

  • 发表日期：

    2026年5月28日

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  • Hang Li,
  • Jing Zhao,
  • Huili Geng,
  • Zihan Chen,
  • Yurui Wang,
  • Fei Liang

摘要

Protein and polypeptides drugs require frequent administration due to low bioavailability and poor stability, leading to reduced patient compliance. We developed a nano-delivery system for the efficient delivery of bovine serum albumin (BSA) based on carboxymethyl-β-cyclodextrin (CM-β-CD) and polyethylene glycol-grafted chitosan (CS-g-mPEG) via polyelectrolyte complexation method. The effects of factors such as volume ratio, pH and grafting degree on particle size, stability, and drug release behavior were investigated. Under optimal conditions, the size of nanoparticle was 223 nm with polydispersity index of 0.131, and the Zeta potential was + 23.86 mV. In vitro release studies demonstrated the nanoparticles can achieve pH-responsive drug release, with release rate of 74.3% in simulated intestinal fluid (pH = 6.8), following the Ritger-Peppas model. Moreover, this nano drug carrier exhibits excellent biocompatibility and long-circulation performance, providing a novel strategy with potential applications for protein drug delivery.