Scholarlink

<p>The aim of this paper was to develop a novel triple network (TN) hydrogel via optimization of the composition of the hydrogel regarding self healing property. Poly hydroxyethyl methacrylate (PHEMA), gelatin and polyvinyl alcohol (PVA) based hydrogels were synthesized as first, second and third network structures respectively. The TN hydrogels were prepared via copolymerization, thermal gelation and freeze-thawing respectively. The three dimensional structure was formed through non-covalent interactions between polymer chains. The Box-Behnken design model was applied to the independent variables of the amounts of poly ethylene glycoldiacrylate (PEGDA) (X1), glutaraldehyde (X2) and gelatin (X3) against a dependent variable (self healing score). The further characterization of the TN hydrogel with ‘best’ self healing capability was performed with SEM, swelling, in-vitro hydrolytic degradation, in vitro cytotoxicity against L929 cell lines and mechanical tests. The cumulative release of lidocaine from TN hydrogel matrix was investigated for 48&#xa0;h. The TN hydrogel with self healing capability, high biocompatibility, highly porous structure, high swelling capacity, moderate mechanical strength presented high potential as a drug delivery vehicle for various biomedical applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Physically crosslinked triple network hydrogels with optimized self healing properties as a drug delivery vehicle

  • 期刊论文

  • 发表日期：

    2026年5月11日

查看全文
  • Aleyna Tuğçe Efecan,
  • Emel Tamahkar,
  • Ecem Çiçek,
  • Batuhan Nuray,
  • Zeynep Ciğeroğlu,
  • Bengi Özkahraman,
  • Elife Kıldalı,
  • Gökçe Taner,
  • Filiz Boran,
  • Safa Şenaysoy,
  • Hüseyin Lekesiz

摘要

The aim of this paper was to develop a novel triple network (TN) hydrogel via optimization of the composition of the hydrogel regarding self healing property. Poly hydroxyethyl methacrylate (PHEMA), gelatin and polyvinyl alcohol (PVA) based hydrogels were synthesized as first, second and third network structures respectively. The TN hydrogels were prepared via copolymerization, thermal gelation and freeze-thawing respectively. The three dimensional structure was formed through non-covalent interactions between polymer chains. The Box-Behnken design model was applied to the independent variables of the amounts of poly ethylene glycoldiacrylate (PEGDA) (X1), glutaraldehyde (X2) and gelatin (X3) against a dependent variable (self healing score). The further characterization of the TN hydrogel with ‘best’ self healing capability was performed with SEM, swelling, in-vitro hydrolytic degradation, in vitro cytotoxicity against L929 cell lines and mechanical tests. The cumulative release of lidocaine from TN hydrogel matrix was investigated for 48 h. The TN hydrogel with self healing capability, high biocompatibility, highly porous structure, high swelling capacity, moderate mechanical strength presented high potential as a drug delivery vehicle for various biomedical applications.