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<p>Diabetic chronic ulcers represent a major clinical challenge due to their complex wound microenvironment and limited therapeutic efficacy. The core impairment stems from a hostile milieu characterized by persistent bacterial infection and hyperglycemia-induced oxidative stress with excessive reactive oxygen species (ROS). Here, we develop an integrated therapeutic hydrogel system to disrupt this vicious cycle. This system employs tetracycline-loaded hollow manganese dioxide-based composite nanozymes (TCH@H-MnO<sub>2</sub>@MPDA-TA) within a cationic guar gum (CG) matrix. The platform orchestrates a synergistic triple-action therapy, in which photothermal activity eradicates bacteria, the manganese dioxide core catalytically scavenges ROS while simultaneously generating hydroxyl radicals for chemodynamic killing, and the controlled release of tetracycline provides potent antibiotic action. This coordinated mechanism endows the composite hydrogel with remarkable antibacterial properties and excellent biocompatibility, demonstrating considerable promise for promoting the healing of diabetic wounds.</p>

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Multimodal synergistic therapy based on TCH@H-MnO2@MPDA-TA/CG composite hydrogel for diabetic chronic wound repair

  • 期刊论文

  • 发表日期：

    2026年5月11日

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  • Liang Xu,
  • Jingyi Hu,
  • Zhaoxiang Tang,
  • Fukang Geng,
  • Wenjing Zhao,
  • Caihong Tao

摘要

Diabetic chronic ulcers represent a major clinical challenge due to their complex wound microenvironment and limited therapeutic efficacy. The core impairment stems from a hostile milieu characterized by persistent bacterial infection and hyperglycemia-induced oxidative stress with excessive reactive oxygen species (ROS). Here, we develop an integrated therapeutic hydrogel system to disrupt this vicious cycle. This system employs tetracycline-loaded hollow manganese dioxide-based composite nanozymes (TCH@H-MnO2@MPDA-TA) within a cationic guar gum (CG) matrix. The platform orchestrates a synergistic triple-action therapy, in which photothermal activity eradicates bacteria, the manganese dioxide core catalytically scavenges ROS while simultaneously generating hydroxyl radicals for chemodynamic killing, and the controlled release of tetracycline provides potent antibiotic action. This coordinated mechanism endows the composite hydrogel with remarkable antibacterial properties and excellent biocompatibility, demonstrating considerable promise for promoting the healing of diabetic wounds.