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<p>This study reports the rational design and fabrication of a novel multifunctional composite hydrogel by integrating copper tripeptide-1 (GHK-Cu) with cellulose nanocrystals (CNC). Fourier-transform infrared spectroscopy and scanning electron microscopy analyses verified the formation of a stable, physically crosslinked three-dimensional network between GHK-Cu and CNC. Mechanical characterization demonstrated outstanding flexibility, with an elongation at break reaching 1303%, markedly superior to that of single-component hydrogels. The composite hydrogel also exhibited a high swelling capacity in physiological saline, achieving a swelling ratio of up to 936%. Furthermore, incorporation of β-cyclodextrin-encapsulated menthol imparted pronounced antibacterial activity to the hydrogel. In addition, the material showed excellent pronounced ABTS radical-scavenging activity (&gt; 95%), whereas the DPPH scavenging response was comparatively modest. Collectively, these results highlight the significant potential of the GHK-Cu/CNC composite hydrogel for applications in wound dressings, tissue engineering, and other biomedical fields.</p> Graphical Abstract <p></p>

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Multifunctional copper tripeptide-1/nanocellulose composite hydrogels

  • 期刊论文

  • 发表日期：

    2026年5月4日

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  • Xinqiao Xia,
  • Lingli Zhang,
  • Chengji Ma,
  • Fangjie Wang,
  • Xinyu Ren,
  • Jia Zhou,
  • Zhongbiao Tan,
  • Ya Xin,
  • Hao Shi

摘要

This study reports the rational design and fabrication of a novel multifunctional composite hydrogel by integrating copper tripeptide-1 (GHK-Cu) with cellulose nanocrystals (CNC). Fourier-transform infrared spectroscopy and scanning electron microscopy analyses verified the formation of a stable, physically crosslinked three-dimensional network between GHK-Cu and CNC. Mechanical characterization demonstrated outstanding flexibility, with an elongation at break reaching 1303%, markedly superior to that of single-component hydrogels. The composite hydrogel also exhibited a high swelling capacity in physiological saline, achieving a swelling ratio of up to 936%. Furthermore, incorporation of β-cyclodextrin-encapsulated menthol imparted pronounced antibacterial activity to the hydrogel. In addition, the material showed excellent pronounced ABTS radical-scavenging activity (> 95%), whereas the DPPH scavenging response was comparatively modest. Collectively, these results highlight the significant potential of the GHK-Cu/CNC composite hydrogel for applications in wound dressings, tissue engineering, and other biomedical fields.

Graphical Abstract