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<p>Droplet evaporation on a substrate can provide valuable information about the physicochemical properties of colloids. In this work, we analyze the evaporation dynamics of complex bio-colloidal samples composed of lipid, protein, and amphiphilic copolymers dispersed in aqueous media to determine their wetting properties and the deposition patterns of their droplets. For this purpose, poly(poly(ethylene glycol) methyl ether acrylate)-<i>block</i>-poly(butyl acrylate) and poly(poly(ethylene glycol) methyl ether acrylate)-<i>block</i>-poly(dodecyl acrylate) amphiphilic block copolymers were synthesized via reversible-addition fragmentation chain-transfer polymerization, where butyl acrylate and dodecyl acrylate represent hydrocarbon chains of different length. Copolymers were combined with 1,2-dimyristoyl-<i>sn</i>-glycero-3-phosphocholine and lysozyme to self-assemble biohybrid vesicles in aqueous media. Measurements of contact angle and contact diameter of aqueous microdroplets derived from the single-components and from mixtures thereof revealed different behaviors. The analyses and obtained results demonstrate that different interfacial and wetting properties emerge when phospholipids, proteins, and copolymers combine to form bio-colloidal systems. Dynamic profiles of the contact angle through the drop evaporation suggest the incorporation of lysozyme and copolymers into the lipid membrane. Interestingly, the chain length associated with the butyl and dodecyl segments of the copolymers influences in a different way the final deposition of the bio-colloidal system. These interfacial properties may be important aspects when formulating biohybrid systems based on biocolloids, for instance, in pharmacological applications.</p> Graphical Abstract <p></p>

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Wetting properties of bio-colloidal suspension droplets of lipid, protein, and copolymers

  • 期刊论文

  • 发表日期：

    2026年3月7日

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  • Ruth Hernández-Pérez,
  • Carolina Ventura-Hunter,
  • A. Jessica Díaz-Salazar,
  • Carlos Guerrero-Sánchez,
  • Ulrich S. Schubert,
  • Enrique Saldívar-Guerra,
  • Rosendo Pérez-Isidoro

摘要

Droplet evaporation on a substrate can provide valuable information about the physicochemical properties of colloids. In this work, we analyze the evaporation dynamics of complex bio-colloidal samples composed of lipid, protein, and amphiphilic copolymers dispersed in aqueous media to determine their wetting properties and the deposition patterns of their droplets. For this purpose, poly(poly(ethylene glycol) methyl ether acrylate)-block-poly(butyl acrylate) and poly(poly(ethylene glycol) methyl ether acrylate)-block-poly(dodecyl acrylate) amphiphilic block copolymers were synthesized via reversible-addition fragmentation chain-transfer polymerization, where butyl acrylate and dodecyl acrylate represent hydrocarbon chains of different length. Copolymers were combined with 1,2-dimyristoyl-sn-glycero-3-phosphocholine and lysozyme to self-assemble biohybrid vesicles in aqueous media. Measurements of contact angle and contact diameter of aqueous microdroplets derived from the single-components and from mixtures thereof revealed different behaviors. The analyses and obtained results demonstrate that different interfacial and wetting properties emerge when phospholipids, proteins, and copolymers combine to form bio-colloidal systems. Dynamic profiles of the contact angle through the drop evaporation suggest the incorporation of lysozyme and copolymers into the lipid membrane. Interestingly, the chain length associated with the butyl and dodecyl segments of the copolymers influences in a different way the final deposition of the bio-colloidal system. These interfacial properties may be important aspects when formulating biohybrid systems based on biocolloids, for instance, in pharmacological applications.

Graphical Abstract