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<p>In this study, a multifunctional composite hydrogel was developed by integrating <i>Hippophae rhamnoides</i> peptides (HRP) with cellulose nanocrystals (CNC), forming a three-dimensional interpenetrating polymer network. The successful formation and structural characteristics of the HRP/CNC hydrogel were confirmed through Fourier-transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction. Mechanical characterization via uniaxial tensile testing demonstrated remarkable extensibility, with an elongation at break reaching 1941%. Swelling behavior studies revealed a high equilibrium swelling ratio of 1119% in phosphate-buffered saline (PBS, pH 7.4), indicative of the hydrogel’s excellent fluid absorption capacity. Furthermore, the composite hydrogel exhibited potent antibacterial activity and outstanding antioxidant performance, with free radical scavenging efficiency exceeding 96%. Owing to its synergistic mechanical strength, bioactivity, and biocompatibility, the HRP/CNC hydrogel presents considerable promise for biomedical applications, particularly in wound healing, controlled drug delivery, and tissue engineering.</p> Graphical abstract <p></p>

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Multifunctional hydrogel based on Hippophae rhamnoides peptides and cellulose nanocrystals

  • 期刊论文

  • 发表日期：

    2025年11月14日

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  • Zilu Xiao,
  • Yanzhao Qian,
  • Jia Zhou,
  • Zhognbiao Tan,
  • Hao Shi,
  • Yegui Zhang

摘要

In this study, a multifunctional composite hydrogel was developed by integrating Hippophae rhamnoides peptides (HRP) with cellulose nanocrystals (CNC), forming a three-dimensional interpenetrating polymer network. The successful formation and structural characteristics of the HRP/CNC hydrogel were confirmed through Fourier-transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction. Mechanical characterization via uniaxial tensile testing demonstrated remarkable extensibility, with an elongation at break reaching 1941%. Swelling behavior studies revealed a high equilibrium swelling ratio of 1119% in phosphate-buffered saline (PBS, pH 7.4), indicative of the hydrogel’s excellent fluid absorption capacity. Furthermore, the composite hydrogel exhibited potent antibacterial activity and outstanding antioxidant performance, with free radical scavenging efficiency exceeding 96%. Owing to its synergistic mechanical strength, bioactivity, and biocompatibility, the HRP/CNC hydrogel presents considerable promise for biomedical applications, particularly in wound healing, controlled drug delivery, and tissue engineering.

Graphical abstract