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<p>Polyethersulfone (PES) membranes are widely used in hemodialysis for their stability and low water adsorption, yet their hydrophobicity promotes protein adsorption and membrane fouling. This study develops an amphiphilic-modified PES membrane (PES/CA-g-AN) grafted with citric acid (hydrophilic) and aniline (hydrophobic) to enhance antifouling performance and solute clearance. Experimental and computational fluid dynamics (CFD) analyses demonstrate that the modified membrane exhibits a 76.43° reduction in water contact angle, indicating significantly improved wettability. The electrostatic attraction between the membrane and protein molecules decreased by approximately 15%, as revealed by density functional theory (DFT). The modified membrane achieved a BSA rejection rate exceeding 97%, along with urea clearance of 85.57% and vitamin B12 clearance of 64.12% under optimized conditions. CFD modeling further quantified the dynamic processes of protein adsorption, pore blockage, and filter cake formation, highlighting a ~ 30% reduction in flux decline compared to pristine PES. These results confirm that amphiphilic modification effectively enhances antifouling properties and solute removal efficiency in hemodialysis membranes.</p>

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Amphiphilic modified PES membrane for promising hemodialysis: anti-fouling performances and clearance

  • 期刊论文

  • 发表日期：

    2025年12月8日

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  • Haoling Huo,
  • Junjie Yang,
  • Yingfei Yang,
  • Wei Li,
  • Chang Liu,
  • Qiwei Wang,
  • Peng Zhang

摘要

Polyethersulfone (PES) membranes are widely used in hemodialysis for their stability and low water adsorption, yet their hydrophobicity promotes protein adsorption and membrane fouling. This study develops an amphiphilic-modified PES membrane (PES/CA-g-AN) grafted with citric acid (hydrophilic) and aniline (hydrophobic) to enhance antifouling performance and solute clearance. Experimental and computational fluid dynamics (CFD) analyses demonstrate that the modified membrane exhibits a 76.43° reduction in water contact angle, indicating significantly improved wettability. The electrostatic attraction between the membrane and protein molecules decreased by approximately 15%, as revealed by density functional theory (DFT). The modified membrane achieved a BSA rejection rate exceeding 97%, along with urea clearance of 85.57% and vitamin B12 clearance of 64.12% under optimized conditions. CFD modeling further quantified the dynamic processes of protein adsorption, pore blockage, and filter cake formation, highlighting a ~ 30% reduction in flux decline compared to pristine PES. These results confirm that amphiphilic modification effectively enhances antifouling properties and solute removal efficiency in hemodialysis membranes.