<p>The current blending polysiloxane softener has not excellent compatibility among molecules with different structures, which leads to an unacceptable modification effect. Regarding this issue, we designed and prepared a nonlinear polysiloxane softener that has the same long-chain, which is relatively free, with traditional polysiloxane softeners, in the hope that it can form effective intermolecular fusion with the latter for an effective and predictable blending modification. This study investigates the tactile characteristics of cotton fabrics treated with linear (SPS) and nonlinear (BPS) polyether-modified polysiloxane softeners. The intermolecular interactions between SPS and BPS were analyzed through thermal properties, particle size distribution, zeta potential, and elemental mapping. The study results demonstrate that molecular entanglement can effectively suppress microphase separation between different compound components, enabling controlled longitudinal distribution of softener components on fiber surfaces. Specifically, the intermolecular interactions between SPS and BPS molecules are clear, and the interaction directly affects the longitudinal distribution tendency of the carbon-ether and silicone-ether segments, which have a large polarity difference, on the cotton fiber surface, thus resulting in different tactile styles. Specially designed in this paper, the entanglement and fusion of softener molecules facilitate uniform longitudinal distribution on the cotton fiber surface, which will contribute to the controlled and predictable tactile properties of cotton textiles. Undoubtedly, this study provides a novel technical approach for the blending modification of traditional polysiloxane softeners.</p> Graphical Abstract <p></p>