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<p>The development of electroconductive sodium alginate (SA)-based composite film has gained significant interest in tissue engineering because of its potential to enhance cell differentiation, proliferation, and tissue regeneration. This work uses green synthesized silver nanoparticles (AgNPs) as a filler to develop a conductive SA-based composite film SA/AgNPs (10, 20, and 30&#xa0;mL) for tissue engineering. The green synthesized AgNPs were confirmed by UV spectra. The composite film was synthesized by a solution-casting method, and AgNPs were homogeneously dispersed in the composite film. Characterization of the films through XRD, FTIR, SEM, and electrical conductivity values demonstrated homogenous distribution of AgNPs. The antibacterial activity and mechanical properties were analyzed for the composite film. The electrical properties of the composite film promoted the alignment and functionality of the cells, making it a suitable material for applications in electrically responsive tissues, such as nerve, muscle, and cardiac tissues. As a result, the tensile strength increases by 83.92 MPa, and electrical conductivity increases by 1.36<i>E</i>−05 for the SA/AgNPs (20&#xa0;mL) composite film. The release test of the composite film exhibited the cumulative release (%) is 13 for 12&#xa0;h. The antioxidant of the SA/AgNPs (20&#xa0;ml) composite film shows 75%. The swelling studies show that the films exhibited controlled water uptake, indicating stability in hydrated environments, and biodegradation analysis revealed the degradation rate, which is crucial for tissue engineering composite film.</p>

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Green synthesis and formation of sodium alginate/silver nanocomposite as electroconductive films with enhanced antibacterial effects for biomedical applications

  • 期刊论文

  • 发表日期：

    2025年9月12日

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  • S. Iswarya,
  • N. Hariram,
  • T. Theivasanthi,
  • Subash C. B. Gopinath

摘要

The development of electroconductive sodium alginate (SA)-based composite film has gained significant interest in tissue engineering because of its potential to enhance cell differentiation, proliferation, and tissue regeneration. This work uses green synthesized silver nanoparticles (AgNPs) as a filler to develop a conductive SA-based composite film SA/AgNPs (10, 20, and 30 mL) for tissue engineering. The green synthesized AgNPs were confirmed by UV spectra. The composite film was synthesized by a solution-casting method, and AgNPs were homogeneously dispersed in the composite film. Characterization of the films through XRD, FTIR, SEM, and electrical conductivity values demonstrated homogenous distribution of AgNPs. The antibacterial activity and mechanical properties were analyzed for the composite film. The electrical properties of the composite film promoted the alignment and functionality of the cells, making it a suitable material for applications in electrically responsive tissues, such as nerve, muscle, and cardiac tissues. As a result, the tensile strength increases by 83.92 MPa, and electrical conductivity increases by 1.36E−05 for the SA/AgNPs (20 mL) composite film. The release test of the composite film exhibited the cumulative release (%) is 13 for 12 h. The antioxidant of the SA/AgNPs (20 ml) composite film shows 75%. The swelling studies show that the films exhibited controlled water uptake, indicating stability in hydrated environments, and biodegradation analysis revealed the degradation rate, which is crucial for tissue engineering composite film.