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<p>Cancer remains a leading cause of mortality worldwide, necessitating the development of innovative and biocompatible therapeutic platforms. This study was motivated by the need to create a multifunctional hydrogel that combines natural polymers and metal–organic frameworks for enhanced anticancer efficacy without external drug loading. Accordingly, a novel composite hydrogel was synthesized using oxidized chitosan, fish collagen peptides, and iridium-based metal–organic frameworks (Ir-MOF). The structure and properties of the hydrogel were characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET), and X-ray diffraction (XRD) analyses, revealing a high-specific surface area (37 m<sup>2</sup>/g), nanoscale crystallite size (79 nm), and thermal stability up to 200°C. Biological evaluation against MCF-7 breast cancer cells demonstrated significant cytotoxicity, with an IC<sub>50</sub> of 156 μg/mL and 24% cell viability at the highest concentration tested. These findings highlight the potential of this drug-free composite hydrogel as an efficient and biocompatible anticancer material, encouraging further in vivo and clinical studies to validate its therapeutic applications.</p> Graphical Abstract <p></p>

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Synthesis of novel composite hydrogel based on chitosan, collagen and iridium-MOF as an efficient anticancer agent

  • 期刊论文

  • 发表日期：

    2025年8月18日

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  • Zahraa Sabah Ghnim,
  • Ayat Hussein Adhab,
  • Jayanti Makasana,
  • Subhash Chandra,
  • Subbulakshmi Ganesan,
  • Aman Shankhyan,
  • Girish Chandra Sharma,
  • Pushpa Negi Bhakuni,
  • Morug Salih Mahdi,
  • Aseel Salah Mansoor,
  • Usama Kadem Radi,
  • Nasr Saadoun Abd,
  • Khursheed Muzammil

摘要

Cancer remains a leading cause of mortality worldwide, necessitating the development of innovative and biocompatible therapeutic platforms. This study was motivated by the need to create a multifunctional hydrogel that combines natural polymers and metal–organic frameworks for enhanced anticancer efficacy without external drug loading. Accordingly, a novel composite hydrogel was synthesized using oxidized chitosan, fish collagen peptides, and iridium-based metal–organic frameworks (Ir-MOF). The structure and properties of the hydrogel were characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET), and X-ray diffraction (XRD) analyses, revealing a high-specific surface area (37 m2/g), nanoscale crystallite size (79 nm), and thermal stability up to 200°C. Biological evaluation against MCF-7 breast cancer cells demonstrated significant cytotoxicity, with an IC50 of 156 μg/mL and 24% cell viability at the highest concentration tested. These findings highlight the potential of this drug-free composite hydrogel as an efficient and biocompatible anticancer material, encouraging further in vivo and clinical studies to validate its therapeutic applications.

Graphical Abstract