Scholarlink

<p>Metal oxide nanoparticles are widely used in various biomedical applications due to their ability to reach unique target positions&#xa0;within the body. In the present work, nickel cobaltite (NiCo<sub>2</sub>O<sub>4</sub>) nanoparticles (NPs) embedded into sodium alginate/gum arabic polymeric hydrogel beads for controlled release of bioactive agents were prepared. These hydrogel beads are comprehensively examined by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analysis. XRD confirmed the generation of NiCo<sub>2</sub>O<sub>4</sub> NPs and integration of NPs into the hydrogel matrix. The TEM studies revealed that the size of NPs is between 25 and 30&#xa0;nm. Swelling studies revealed that hydrogel beads exhibit pH-dependent behaviour, which is suitable for controlled drug release in various physiological conditions. In vitro release tests revealed a higher release rate at pH 7.4 compared to pH 2.0. Using doxorubicin as a model drug, cytotoxic effects on human breast cancer cells were examined. The developed NPs-loaded hydrogel beads effectively prevent the growth of breast cancer cells, such as Michigan Cancer Foundation-7 (MCF-7) cells with a viability of 9.5%. Furthermore, the biocompatibility of NPs and sodium alginate/gum arabic hydrogel beads conducted with 3T3 fibroblast cells has shown that cell viability is more than 80%, indicating the biocompatibility of hydrogel beads. These hydrogel beads need to warrant further development as carriers for pH-responsive and controlled release of bioactive agents.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Ionically cross-linked pH-responsive hydrogel beads loaded with nickel cobaltite nanoparticles for controlled release of doxorubicin

  • 期刊论文

  • 发表日期：

    2025年6月11日

查看全文
  • Eppa Venkata Ramana,
  • Guntakanti Ujwala,
  • Thammineni Jithendra,
  • Shaik Shahinshavali,
  • Dandamudi Srilaxmi,
  • Obireddy Sreekanth Reddy,
  • Naseem

摘要

Metal oxide nanoparticles are widely used in various biomedical applications due to their ability to reach unique target positions within the body. In the present work, nickel cobaltite (NiCo2O4) nanoparticles (NPs) embedded into sodium alginate/gum arabic polymeric hydrogel beads for controlled release of bioactive agents were prepared. These hydrogel beads are comprehensively examined by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analysis. XRD confirmed the generation of NiCo2O4 NPs and integration of NPs into the hydrogel matrix. The TEM studies revealed that the size of NPs is between 25 and 30 nm. Swelling studies revealed that hydrogel beads exhibit pH-dependent behaviour, which is suitable for controlled drug release in various physiological conditions. In vitro release tests revealed a higher release rate at pH 7.4 compared to pH 2.0. Using doxorubicin as a model drug, cytotoxic effects on human breast cancer cells were examined. The developed NPs-loaded hydrogel beads effectively prevent the growth of breast cancer cells, such as Michigan Cancer Foundation-7 (MCF-7) cells with a viability of 9.5%. Furthermore, the biocompatibility of NPs and sodium alginate/gum arabic hydrogel beads conducted with 3T3 fibroblast cells has shown that cell viability is more than 80%, indicating the biocompatibility of hydrogel beads. These hydrogel beads need to warrant further development as carriers for pH-responsive and controlled release of bioactive agents.

Graphical Abstract