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<p>A drug delivery formulation is proposed to enhance the therapeutic efficacy of prednisolone while minimizing associated side effects. The method involves making a depolymerized hyaluronic acid conjugated poly(lactic-co-glycolic acid) (dp-HA-<i>g</i>-PLGA) copolymer with a hyaluronan-rich surface that can bind to CD44 receptors. The hydrophobic backbone of PLGA is chemically linked to partially depolymerized hyaluronic acid [dp-HA], augmenting the copolymer’s interaction with CD44 receptors. Prednisolone (PSL)-encapsulated dp-HA-<i>g</i>-PLGA nanoparticles (NPs) were prepared by the single emulsion technique and characterized for key parameters such as size, morphology, drug-loading efficiency, and drug release kinetics study. The average size of the PSL-encapsulated dp-HA-<i>g</i>-PLGA was identified as 271&#xa0;nm with 74.7% encapsulation efficacy and 6.47% drug-loading efficacy. Furthermore, in vitro assays identify the biocompatibility of the nanoparticles in RAW 264.7 cells. Thus, the findings demonstrate the effectiveness of dp-HA<i>-g</i>-PLGA nanoparticles as a drug carrier for biomedical applications.</p> Graphical abstract <p></p>

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Preparation, characterization and in vitro evaluation of poly[lactic-co-(glycolic acid)] (PLGA) nanoparticles conjugated with depolymerized hyaluronic acid for drug delivery

  • 期刊论文

  • 发表日期：

    2025年1月18日

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  • X. Janet Bertilla,
  • S. Rupachandra

摘要

A drug delivery formulation is proposed to enhance the therapeutic efficacy of prednisolone while minimizing associated side effects. The method involves making a depolymerized hyaluronic acid conjugated poly(lactic-co-glycolic acid) (dp-HA-g-PLGA) copolymer with a hyaluronan-rich surface that can bind to CD44 receptors. The hydrophobic backbone of PLGA is chemically linked to partially depolymerized hyaluronic acid [dp-HA], augmenting the copolymer’s interaction with CD44 receptors. Prednisolone (PSL)-encapsulated dp-HA-g-PLGA nanoparticles (NPs) were prepared by the single emulsion technique and characterized for key parameters such as size, morphology, drug-loading efficiency, and drug release kinetics study. The average size of the PSL-encapsulated dp-HA-g-PLGA was identified as 271 nm with 74.7% encapsulation efficacy and 6.47% drug-loading efficacy. Furthermore, in vitro assays identify the biocompatibility of the nanoparticles in RAW 264.7 cells. Thus, the findings demonstrate the effectiveness of dp-HA-g-PLGA nanoparticles as a drug carrier for biomedical applications.

Graphical abstract