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Background/Objective <p>Trans fatty acids (TFA), a by-product of partial hydrogenation, have been proven to contribute significant adverse effects on human health. Interesterification has been used as an alternative to hardening edible oils instead of partial hydrogenation. There are limited reports of the impacts of interesterified fat consumption on inflammatory biomarkers. We compared the effects of chemically interesterified fats rich in palmitic (CIEPO) and stearic acid (CIEBlend) with native palm olein (POo) diets on selected inflammatory related biomarkers of 90 healthy adults.</p> Methods <p>We used a double-blind, parallel feeding intervention trial using 50&#xa0;g of each test fat in the form of margarine, separately incorporated into two servings of snacks for breakfast and afternoon tea daily for eight weeks. Blood samples were collected at baseline, zero-, sixth- and eighth-week.</p> Results <p>POo-, CIEPO- and CIEBlend-diets produce no significant difference in the serum levels of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), visfatin and high-sensitivity C-reactive protein (hsCRP).</p> Conclusions <p>The finding suggests that the long-term effects of these three fats on these selected inflammatory related biomarkers are similar.</p> <p><i>Trial registration</i> <a href="https://clinicaltrials.gov/">https://clinicaltrials.gov/</a>, NCT02192047, 2014-07-15.</p>

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Interesterified fats rich in palmitic and stearic acids have comparable effects on selected inflammatory related biomarkers

  • 期刊论文

  • 发表日期：

    2026年7月3日

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  • Yen Teng Ng,
  • Phooi Tee Voon,
  • Tony Kock Wai Ng,
  • Verna Kar Mun Lee,
  • Miskandar Mat Sahri,
  • Norhaizan Mohd Esa

摘要

Background/Objective

Trans fatty acids (TFA), a by-product of partial hydrogenation, have been proven to contribute significant adverse effects on human health. Interesterification has been used as an alternative to hardening edible oils instead of partial hydrogenation. There are limited reports of the impacts of interesterified fat consumption on inflammatory biomarkers. We compared the effects of chemically interesterified fats rich in palmitic (CIEPO) and stearic acid (CIEBlend) with native palm olein (POo) diets on selected inflammatory related biomarkers of 90 healthy adults.

Methods

We used a double-blind, parallel feeding intervention trial using 50 g of each test fat in the form of margarine, separately incorporated into two servings of snacks for breakfast and afternoon tea daily for eight weeks. Blood samples were collected at baseline, zero-, sixth- and eighth-week.

Results

POo-, CIEPO- and CIEBlend-diets produce no significant difference in the serum levels of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), visfatin and high-sensitivity C-reactive protein (hsCRP).

Conclusions

The finding suggests that the long-term effects of these three fats on these selected inflammatory related biomarkers are similar.

Trial registration https://clinicaltrials.gov/, NCT02192047, 2014-07-15.