Scholarlink

Purpose <p>This randomized, double-blind, placebo-controlled trial investigated the effects of <i>Curcuma longa</i> extract (CLE) supplementation on vascular, redox-inflammatory biomarkers, and neuropathy symptoms in adults with type 2 diabetes mellitus (T2DM).</p> Methods <p>Seventy-six adults with T2DM were randomized to receive CLE (1200&#xa0;mg/day) or placebo for three months. Plasma concentrations of hyaluronic acid (HA), syndecan-1 (SDC1), syndecan-4 (SDC4), matrix metalloproteinases (MMP-2 and MMP-9), thioredoxin-1 (Trx1), thioredoxin-binding protein-2 (TBP2), sirtuin-1 (SIRT1), nuclear factor erythroid 2–related factor 2 (Nrf2), and the p65 subunit of nuclear factor kappa B (NF-κB p65) were measured at baseline and post-intervention. Neuropathy symptoms were assessed using a validated questionnaire.</p> Results <p>Baseline characteristics were comparable between groups. After 3&#xa0;months, CLE supplementation resulted in a significant reduction in neuropathy symptom score compared with placebo (<i>P</i> = 0.048). CLE significantly reduced markers of endothelial glycocalyx shedding, including SDC1 (66.5 vs. 113.0&#xa0;ng/mL; <i>P</i> = 0.001), SDC4 (155.1 vs. 225.5&#xa0;pg/mL; <i>P</i> = 0.040), and HA (259.8 vs. 371.7&#xa0;ng/mL; <i>P</i> = 0.002), as well as MMP-2 (198.4 vs. 233.3&#xa0;ng/mL; <i>P</i> &lt; 0.001) and MMP-9 (1.2 vs. 2.0&#xa0;ng/mL; <i>P</i> &lt; 0.001). In parallel, CLE increased antioxidant/redox markers Trx1, SIRT1, and Nrf2 (all <i>P</i> &lt; 0.05) and reduced TBP2 and NF-κB p65 levels (both <i>P</i> &lt; 0.001), indicating coordinated modulation of vascular, redox, and inflammatory pathways.</p> Conclusion <p>Short-term supplementation with CLE was associated with favorable modulation of vascular and redox-inflammatory biomarkers and improvement in neuropathy symptoms in adults with T2DM. These findings support the role of CLE as a promising bioactive nutritional supplement for the prevention and management of vascular and neuropathic complications associated with diabetes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Curcuma longa improves endothelial glycocalyx integrity and redox-inflammatory pathways in type 2 diabetes mellitus: a randomized double-blind placebo-controlled study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月15日

查看全文
  • Drielly Rodrigues Viudes,
  • Alanna Ramalho Mateus,
  • Cristina Antoniali Silva,
  • Maria do Carmo Franco

摘要

Purpose

This randomized, double-blind, placebo-controlled trial investigated the effects of Curcuma longa extract (CLE) supplementation on vascular, redox-inflammatory biomarkers, and neuropathy symptoms in adults with type 2 diabetes mellitus (T2DM).

Methods

Seventy-six adults with T2DM were randomized to receive CLE (1200 mg/day) or placebo for three months. Plasma concentrations of hyaluronic acid (HA), syndecan-1 (SDC1), syndecan-4 (SDC4), matrix metalloproteinases (MMP-2 and MMP-9), thioredoxin-1 (Trx1), thioredoxin-binding protein-2 (TBP2), sirtuin-1 (SIRT1), nuclear factor erythroid 2–related factor 2 (Nrf2), and the p65 subunit of nuclear factor kappa B (NF-κB p65) were measured at baseline and post-intervention. Neuropathy symptoms were assessed using a validated questionnaire.

Results

Baseline characteristics were comparable between groups. After 3 months, CLE supplementation resulted in a significant reduction in neuropathy symptom score compared with placebo (P = 0.048). CLE significantly reduced markers of endothelial glycocalyx shedding, including SDC1 (66.5 vs. 113.0 ng/mL; P = 0.001), SDC4 (155.1 vs. 225.5 pg/mL; P = 0.040), and HA (259.8 vs. 371.7 ng/mL; P = 0.002), as well as MMP-2 (198.4 vs. 233.3 ng/mL; P < 0.001) and MMP-9 (1.2 vs. 2.0 ng/mL; P < 0.001). In parallel, CLE increased antioxidant/redox markers Trx1, SIRT1, and Nrf2 (all P < 0.05) and reduced TBP2 and NF-κB p65 levels (both P < 0.001), indicating coordinated modulation of vascular, redox, and inflammatory pathways.

Conclusion

Short-term supplementation with CLE was associated with favorable modulation of vascular and redox-inflammatory biomarkers and improvement in neuropathy symptoms in adults with T2DM. These findings support the role of CLE as a promising bioactive nutritional supplement for the prevention and management of vascular and neuropathic complications associated with diabetes.