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Purpose <p> We aimed to investigate the relationship between habitual glucosamine use and the risk of incident idiopathic pulmonary fibrosis (IPF). Moreover, we assessed the modification effect of genetic predisposition on such association.</p> Methods <p>We analyzed 472,615 individuals from the UK Biobank. The genetic risk score (GRS) for IPF was constructed. The Cox proportional hazard models were fitted to estimate the association.</p> Results <p>During a median of 12.5 years of follow-up, 1870 incident cases of IPF were identified. After adjusting for potential covariates, we observed that glucosamine intake was related to a reduced risk of IPF. Moreover, an additive interaction and joint effect were observed between non-users of glucosamine and genetic susceptibility on the development of IPF.</p> Conclusion <p>These findings suggested that habitual glucosamine consumption was related to a lower incidence of IPF, and this relationship could be influenced by genetic susceptibility.</p>

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Relationship between habitual glucosamine use and risk of incident idiopathic pulmonary fibrosis with the modification effect of genetic susceptibility: a prospective cohort study

  • 期刊论文

  • 发表日期：

    2026年3月7日

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  • Liangle Yang,
  • Yujia Xie,
  • Yuxin Yao,
  • Haoyu Yin,
  • Bingxin Shang,
  • Shiyu Yang,
  • Xiaojie You,
  • Jixuan Ma

摘要

Purpose

We aimed to investigate the relationship between habitual glucosamine use and the risk of incident idiopathic pulmonary fibrosis (IPF). Moreover, we assessed the modification effect of genetic predisposition on such association.

Methods

We analyzed 472,615 individuals from the UK Biobank. The genetic risk score (GRS) for IPF was constructed. The Cox proportional hazard models were fitted to estimate the association.

Results

During a median of 12.5 years of follow-up, 1870 incident cases of IPF were identified. After adjusting for potential covariates, we observed that glucosamine intake was related to a reduced risk of IPF. Moreover, an additive interaction and joint effect were observed between non-users of glucosamine and genetic susceptibility on the development of IPF.

Conclusion

These findings suggested that habitual glucosamine consumption was related to a lower incidence of IPF, and this relationship could be influenced by genetic susceptibility.