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Purpose <p>While orange juice has been reported to decrease serum uric acid (SUA), the effects of the specific constituents hesperidin and vitamin C are not fully understood. The present study aimed to unravel their possible SUA-lowering effects.</p> Methods <p>In a randomized controlled, double-blind, two-way cross-over, two-week intervention, the effects of four orange-flavored drinks (200 mL/d) on SUA (primary outcome) were compared in 40 adults (21–78 y; BMI 17.9–41.4&#xa0;kg/m<sup>2</sup>) with high SUA. One drink was a placebo; the others contained 600&#xa0;mg vitamin C (<i>VitC</i>), 240&#xa0;mg hesperidin (<i>Hesp</i>), or both (<i>VitC+Hesp</i>). Blood and urine concentrations of uric acid, vitamin C, and hesperidin metabolites were measured, along with the HOMA index as a potential confounder.</p> Results <p><i>VitC</i> increased plasma vitamin C levels, <i>Hesp</i> increased urinary excretion of hesperidin metabolites, and <i>VitC+Hesp</i> increased both. Higher baseline plasma vitamin C levels resulted in diminished increases in vitamin C (<i>VitC</i>: <i>r</i> = -0.53; <i>p</i> = 0.02 and <i>VitC+Hesp</i>: <i>r</i> = -0.79; <i>p</i> &lt; 0.001). Levels of SUA decreased in response to <i>VitC</i> and <i>VitC+Hesp</i> with no changes in urinary uric acid excretion (UUA) or clearance (UAC). The increase in plasma vitamin C was associated with a decrease in SUA (<i>r</i> = -0.25; <i>p</i> &lt; 0.03) with larger effects at higher baseline SUA (<i>r</i> = -0.24; <i>p</i> = 0.03). A high HOMA index was associated with lower plasma vitamin C and elevated SUA.</p> Conclusion <p>Vitamin C but not hesperidin decreased serum uric acid levels without affecting uric acid excretion.</p> Clinical Trials registration <p><a href="http://www.clinicaltrials.gov">www.clinicaltrials.gov</a>; NCT04316390; July 15, 2022.</p>

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Effect of vitamin C and hesperidin on serum uric acid concentrations in healthy adults with high uric acid levels: the randomized controlled ‘HesperidrinC trial’

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月25日

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  • Janna Enderle,
  • Rebecca Dörner,
  • Daria Tondar,
  • Mario Hasler,
  • Caroline Gilcher,
  • Christof B. Steingass,
  • Ralf Schweiggert,
  • Manfred J. Müller,
  • Anja Bosy-Westphal

摘要

Purpose

While orange juice has been reported to decrease serum uric acid (SUA), the effects of the specific constituents hesperidin and vitamin C are not fully understood. The present study aimed to unravel their possible SUA-lowering effects.

Methods

In a randomized controlled, double-blind, two-way cross-over, two-week intervention, the effects of four orange-flavored drinks (200 mL/d) on SUA (primary outcome) were compared in 40 adults (21–78 y; BMI 17.9–41.4 kg/m2) with high SUA. One drink was a placebo; the others contained 600 mg vitamin C (VitC), 240 mg hesperidin (Hesp), or both (VitC+Hesp). Blood and urine concentrations of uric acid, vitamin C, and hesperidin metabolites were measured, along with the HOMA index as a potential confounder.

Results

VitC increased plasma vitamin C levels, Hesp increased urinary excretion of hesperidin metabolites, and VitC+Hesp increased both. Higher baseline plasma vitamin C levels resulted in diminished increases in vitamin C (VitC: r = -0.53; p = 0.02 and VitC+Hesp: r = -0.79; p < 0.001). Levels of SUA decreased in response to VitC and VitC+Hesp with no changes in urinary uric acid excretion (UUA) or clearance (UAC). The increase in plasma vitamin C was associated with a decrease in SUA (r = -0.25; p < 0.03) with larger effects at higher baseline SUA (r = -0.24; p = 0.03). A high HOMA index was associated with lower plasma vitamin C and elevated SUA.

Conclusion

Vitamin C but not hesperidin decreased serum uric acid levels without affecting uric acid excretion.

Clinical Trials registration

www.clinicaltrials.gov; NCT04316390; July 15, 2022.