Purpose <p>Few studies have examined the association between dietary nutrients and subjective cognitive complaints (SCCs), which are potential predictors of Alzheimer’s disease-related dementia (ADRD). We aimed to examine the association of midlife intake of macronutrients, as well as of a few other nutrients, with SCC development.</p> Methods <p>We included 5119 participants who responded to the 2018 or 2020 follow-up questionnaire of the New York University Women’s Health Study. Dietary data were collected using a validated self-administered Block food frequency questionnaire, and nutrient intake were calculated using food lists and food composition tables. SCCs were assessed using a standardized questionnaire.</p> Results <p>Dietary intakes of fiber, carbohydrates, and potassium were inversely associated with having ≥ 2 SCC (<i>p</i>-trend = 0.0047, 0.026, and 0.0015, respectively), whereas higher intakes of total fat and saturated fat, as well as a higher ratio of fat to carbohydrates, were positively associated with ≥ 2 SCCs (<i>p</i>-trend = &lt; 0.0001, 0.0015, and 0.0025, respectively). The positive associations of total fat intake and the log-ratio of fat to carbohydrates with ≥ 2 SCCs remained significant after controlling for other nutrients (<i>p</i>-trend = 0.008 and 0.036, respectively). The association between total fat intake and SCCs was stronger among participants with lower caloric intake (&lt; median = 1430&#xa0;kcal) compared with those consuming higher intake (≥ 1430&#xa0;kcal) (<i>p</i>-value for interaction = 0.0049). The associations did not differ appreciably by other factors.</p> Conclusion <p>We observed a positive association between midlife dietary fat intakes and SCCs in later life in a cohort of women.</p>