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Purpose <p>Obesity and associated metabolic disorders represent a major global health challenge. The objective of this study was to determine the efficacy of a Multifaceted Lifestyle Program (MLP, combining dietary advice and supplementation with dietary fibre, probiotics and chromium) on weight, body composition and markers of metabolic health in overweight adults.</p> Methods <p>Fifty-seven overweight adults (BMI 25–29.9&#xa0;kg/m<sup>2</sup>, aged 19–65&#xa0;years) participated in an 8-week intervention trial, with 50 completing the study. Participants were randomised into three groups (A–C): A: placebo (rice powder; control); B: MLP + BioPB (an equal part blend of carrageenan, konjac and cellulose); and C: MLP + P (psyllium fibre). The primary outcome was changes in anthropometric and metabolic health indices at 4 and 8&#xa0;weeks. The secondary outcome was the effect of the different fibres.</p> Results <p>At week 4, participants receiving MLP + P and MLP + BioPB exhibited significant reductions (<i>p</i> &lt; 0.001) in body weight (− 4.8&#xa0;kg; and − 5.1&#xa0;kg, respectively), BMI (− 1.7&#xa0;kg/m<sup>2</sup> and − 1.7&#xa0;kg/m<sup>2</sup>, respectively), body fat mass (− 3.7 kg and − 4.2&#xa0;kg) and visceral fat scores (− 1.9 and − 2.4). Some lean tissue mass loss was also evident. These changes were sustained for 4&#xa0;weeks post-intervention. MLP + P and MLP + BioPB showed differing effects on blood lipids and inflammatory markers: reductions in cholesterol and LDL-cholesterol were greater and more persistent in the MLP + BioPB group, whereas the CRP levels (high CRP levels are linked to&#xa0;inflammation and metabolic disorders) were significantly reduced in the MLP + P group only. Significant improvements were also observed in the liver and kidney functions. No notable changes were observed in any parameters in the control group.</p> Conclusion <p>The MLP, incorporating fibre supplementation, produced clinically significant improvements in body weight, BMI and body fat in overweight adults, offering a practical strategy for managing obesity. Importantly, the type of dietary fibre used had distinct metabolic effects, underscoring the need for tailored fibre interventions to optimise metabolic health.</p>

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A multifaceted lifestyle program for weight loss in overweight adults: evidence from a randomised clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月12日

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  • Harsharn Gill,
  • Chintha Lankatillake,
  • Elena Zafiris,
  • Christopher Pillidge

摘要

Purpose

Obesity and associated metabolic disorders represent a major global health challenge. The objective of this study was to determine the efficacy of a Multifaceted Lifestyle Program (MLP, combining dietary advice and supplementation with dietary fibre, probiotics and chromium) on weight, body composition and markers of metabolic health in overweight adults.

Methods

Fifty-seven overweight adults (BMI 25–29.9 kg/m2, aged 19–65 years) participated in an 8-week intervention trial, with 50 completing the study. Participants were randomised into three groups (A–C): A: placebo (rice powder; control); B: MLP + BioPB (an equal part blend of carrageenan, konjac and cellulose); and C: MLP + P (psyllium fibre). The primary outcome was changes in anthropometric and metabolic health indices at 4 and 8 weeks. The secondary outcome was the effect of the different fibres.

Results

At week 4, participants receiving MLP + P and MLP + BioPB exhibited significant reductions (p < 0.001) in body weight (− 4.8 kg; and − 5.1 kg, respectively), BMI (− 1.7 kg/m2 and − 1.7 kg/m2, respectively), body fat mass (− 3.7 kg and − 4.2 kg) and visceral fat scores (− 1.9 and − 2.4). Some lean tissue mass loss was also evident. These changes were sustained for 4 weeks post-intervention. MLP + P and MLP + BioPB showed differing effects on blood lipids and inflammatory markers: reductions in cholesterol and LDL-cholesterol were greater and more persistent in the MLP + BioPB group, whereas the CRP levels (high CRP levels are linked to inflammation and metabolic disorders) were significantly reduced in the MLP + P group only. Significant improvements were also observed in the liver and kidney functions. No notable changes were observed in any parameters in the control group.

Conclusion

The MLP, incorporating fibre supplementation, produced clinically significant improvements in body weight, BMI and body fat in overweight adults, offering a practical strategy for managing obesity. Importantly, the type of dietary fibre used had distinct metabolic effects, underscoring the need for tailored fibre interventions to optimise metabolic health.