Purpose <p>Eczema is a systemic condition associated with an increased risk of eye diseases. Xanthophylls and other antioxidants are eye-beneficial, and eggs are an excellent source of xanthophylls, often fortified to enhance their benefits. However, the effects of antioxidant-rich egg consumption on eye health in individuals with eczema have not been clinically validated. This study examined the effects of consuming regular eggs and antioxidant-fortified eggs on eye health in individuals with mild to moderate eczema via a 12&#xa0;weeks, double-blind, randomized controlled trial.</p> Methods <p>Forty adults were randomized into two groups: the intervention group (<i>n</i> = 21) consumed two antioxidant-fortified eggs daily and the regular egg group (<i>n</i> = 19) consumed two regular eggs daily. Macular pigment optical density (MPOD), best corrected visual acuity (BCVA), contrast sensitivity (CS), photostress recovery time (PSR) and visual function questionnaire (VFQ25) were assessed every 3&#xa0;weeks. Plasma levels of xanthophylls and fortified antioxidants, and nutrient intakes from the basal diet were assessed every 6&#xa0;weeks.</p> Results <p>Over the 12&#xa0;weeks period, significant time effects showed improvements in MPOD, CS primarily driven by the regular egg group, and PSR mainly in by the intervention group. Both groups showed increases in VFQ25 composite scores and plasma xanthophyll concentrations. However, no differences over time were observed in BCVA, plasma fortified-antioxidants concentrations, or basal diet antioxidant intakes were observed between groups.</p> Conclusion <p>Daily consumption of two eggs improves eye health-related parameters, while antioxidant-fortified eggs provide additional benefits in PSR. Eggs may serve as a beneficial dietary strategy for improving eye health. </p> <p><i>Trial registration</i>: Clinicaltrials.gov: NCT05913791.</p>