Scholarlink

Purpose <p>A growing body of evidence suggests diets rich in flavonoids may protect against metabolic-dysfunction associated steatotic liver disease (MASLD) development and progression. As the gut microbiome is important in the biotransformation of flavonoids to their constituent bioactive metabolites, studies on the potential mediating role of the gut microbiome in the association between dietary flavonoid intakes and MASLD are warranted but lacking. Thus, this study aims to examine the associations between a diet rich in flavonoids and MASLD, and assess the potential mediating role of the gut microbiome.</p> Methods <p>In a cross-sectional analysis (n = 531), using the FlavoDiet score (FDS), we assessed the association between a flavonoid-rich diet and MASLD (ascertained by magnetic resonance imaging) using multivariable logistic and linear regression. Additionally, we used mediation analysis to identify and assess potential 16S-derived gut microbiome mediators.</p> Results <p>Each doubling of the FDS was associated with a 27% lower odds of MASLD (OR: 0.73 [95% CI 0.54–0.98], <i>p</i> = 0.04) after multivariable adjustment. 9.2% of this association was mediated by a greater abundance of the genus <i>Eisenbergiella</i> (indirect effect ß = − 0.006 [95% CI − 0.019, to − 0.000], <i>p</i> = 0.04).</p> Conclusion <p>These findings suggest that a flavonoid-rich diet is associated with better liver health, and that the abundance of the <i>Eisenbergiella</i> taxa may in part explain the association between a flavonoid-rich diet and MASLD.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The gut microbiome mediates the association between a flavonoid-rich diet and MASLD in a population-level analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月4日

查看全文
  • William Bell,
  • Amy Jennings,
  • Nicola P. Bondonno,
  • Andre Franke,
  • Corinna Bang,
  • Marcus Both,
  • Jan Kassubek,
  • Hans-Peter Müller,
  • Jan Borggrefe,
  • Wolfgang Lieb,
  • Tilman Kühn,
  • Aedín Cassidy

摘要

Purpose

A growing body of evidence suggests diets rich in flavonoids may protect against metabolic-dysfunction associated steatotic liver disease (MASLD) development and progression. As the gut microbiome is important in the biotransformation of flavonoids to their constituent bioactive metabolites, studies on the potential mediating role of the gut microbiome in the association between dietary flavonoid intakes and MASLD are warranted but lacking. Thus, this study aims to examine the associations between a diet rich in flavonoids and MASLD, and assess the potential mediating role of the gut microbiome.

Methods

In a cross-sectional analysis (n = 531), using the FlavoDiet score (FDS), we assessed the association between a flavonoid-rich diet and MASLD (ascertained by magnetic resonance imaging) using multivariable logistic and linear regression. Additionally, we used mediation analysis to identify and assess potential 16S-derived gut microbiome mediators.

Results

Each doubling of the FDS was associated with a 27% lower odds of MASLD (OR: 0.73 [95% CI 0.54–0.98], p = 0.04) after multivariable adjustment. 9.2% of this association was mediated by a greater abundance of the genus Eisenbergiella (indirect effect ß = − 0.006 [95% CI − 0.019, to − 0.000], p = 0.04).

Conclusion

These findings suggest that a flavonoid-rich diet is associated with better liver health, and that the abundance of the Eisenbergiella taxa may in part explain the association between a flavonoid-rich diet and MASLD.