Scholarlink

Purpose <p>Maternal nutrition during pregnancy is key for offspring neurodevelopment. Given the role of glucose in brain function, assessing carbohydrate quantity and quality, including glycemic index (GI), glycemic load (GL) and carbohydrate quality index (CQI), may provide insights into early brain development. This study examined the associations between maternal dietary carbohydrate intake and neurodevelopmental outcomes in early childhood.</p> Methods <p>The prospective cohort study included 1080 mother–child pairs from the Barcelona Life Study Cohort. Maternal dietary carbohydrate intake, GI, GL and CQI were assessed during mid-pregnancy using a food frequency questionnaire. Child neurodevelopment was evaluated at 8 and 28&#xa0;months using the Developmental Profile 3 (DP-3) and at 18&#xa0;months using the Bayley Scales of Infant and Toddler Development (BSID-III). Associations were analyzed using multivariable linear regression models adjusted for relevant maternal and child covariates.</p> Results <p>Increased maternal carbohydrate intake, GI, and GL were inversely associated with language development (β (95% CI): −&#xa0;2.67 (−&#xa0;5.13, −&#xa0;0.21), −&#xa0;2.73 (−&#xa0;5.21, −&#xa0;0.26), −&#xa0;3.51 (−&#xa0;5.96, −&#xa0;1.07) respectively) and receptive language (β (95% CI): −&#xa0;0.58 (−&#xa0;1.07, −&#xa0;0.08), −&#xa0;0.54 (−&#xa0;1.04, −&#xa0;0.04), −&#xa0;0.70 (−&#xa0;1.20, −&#xa0;0.21) respectively) at 18&#xa0;months, as measured by the BSID-III, although these associations were attenuated after adjustment for maternal and child covariates. Increased GI and lower CQI were associated with lower gross motor scores (β (95% CI): −&#xa0;0.49 (−&#xa0;0.84, −&#xa0;0.15), 0.39 (0.06, 0.71) respectively) at 18&#xa0;months (BSID-III), as well as reduced motor development (β (95% CI): −&#xa0;3.2 (−&#xa0;5.50, −&#xa0;0.76), 2.22 (−&#xa0;0.1, 4.54) respectively) at 8 and 28&#xa0;months (DP-3).</p> Conclusions <p>Maternal carbohydrate quality during pregnancy may influence early neurodevelopment, particularly motor outcomes. Emphasizing low-GI, low-GL and high-CQI carbohydrate sources during pregnancy could support favorable developmental trajectories in offspring.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Exploring the relationship between maternal carbohydrate quality and quantity during pregnancy and early childhood neurodevelopment: a prospective cohort study within the BiSC cohort

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月1日

查看全文
  • Laura Panisello,
  • Javier Mateu-Fabregat,
  • Nil Novau-Ferré,
  • Nicolas Ayala-Aldana,
  • Sara Bernardo-Castro,
  • Muriel Ferrer,
  • Pol Jiménez-Arenas,
  • Elisa Llurba,
  • Camille Lassale,
  • María Dolores Gómez-Roig,
  • Jesús Vioque,
  • Sandra González-Palacios,
  • Oren Contreras-Rodríguez,
  • Maria Foraster,
  • Mireia Gascon,
  • Jordi Sunyer,
  • Camila Awad,
  • Jordi Júlvez,
  • Mònica Bulló

摘要

Purpose

Maternal nutrition during pregnancy is key for offspring neurodevelopment. Given the role of glucose in brain function, assessing carbohydrate quantity and quality, including glycemic index (GI), glycemic load (GL) and carbohydrate quality index (CQI), may provide insights into early brain development. This study examined the associations between maternal dietary carbohydrate intake and neurodevelopmental outcomes in early childhood.

Methods

The prospective cohort study included 1080 mother–child pairs from the Barcelona Life Study Cohort. Maternal dietary carbohydrate intake, GI, GL and CQI were assessed during mid-pregnancy using a food frequency questionnaire. Child neurodevelopment was evaluated at 8 and 28 months using the Developmental Profile 3 (DP-3) and at 18 months using the Bayley Scales of Infant and Toddler Development (BSID-III). Associations were analyzed using multivariable linear regression models adjusted for relevant maternal and child covariates.

Results

Increased maternal carbohydrate intake, GI, and GL were inversely associated with language development (β (95% CI): − 2.67 (− 5.13, − 0.21), − 2.73 (− 5.21, − 0.26), − 3.51 (− 5.96, − 1.07) respectively) and receptive language (β (95% CI): − 0.58 (− 1.07, − 0.08), − 0.54 (− 1.04, − 0.04), − 0.70 (− 1.20, − 0.21) respectively) at 18 months, as measured by the BSID-III, although these associations were attenuated after adjustment for maternal and child covariates. Increased GI and lower CQI were associated with lower gross motor scores (β (95% CI): − 0.49 (− 0.84, − 0.15), 0.39 (0.06, 0.71) respectively) at 18 months (BSID-III), as well as reduced motor development (β (95% CI): − 3.2 (− 5.50, − 0.76), 2.22 (− 0.1, 4.54) respectively) at 8 and 28 months (DP-3).

Conclusions

Maternal carbohydrate quality during pregnancy may influence early neurodevelopment, particularly motor outcomes. Emphasizing low-GI, low-GL and high-CQI carbohydrate sources during pregnancy could support favorable developmental trajectories in offspring.