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Purpose <p>Genes associated with body mass index (BMI), including <i>FTO rs9939609,</i><i>MC4R</i> rs17782313, and <i>BDNF</i> rs6265, may influence BMI and regulate energy metabolism. While previous studies have explored health-related behavior changes, few have investigated both biochemical and behavior changes resulting from perceived genetic risk. This study investigated whether recognizing BMI-related genes affects health-related behaviors and alters blood metabolite levels.</p> Methods <p>Normal and overweight adults aged 25–35 years (<i>n</i> = 100) were randomly assigned to an intervention group (<i>n</i> = 65) informed about BMI-related genetic information (<i>FTO</i> rs9939609, <i>MC4R</i> rs17782313, <i>BDNF</i> rs6265) and an uninformed group (<i>n</i> = 35, CON). The intervention group was further divided into Intervention-high risk (IHR, <i>n</i> = 36) and intervention-low risk (ILR, <i>n</i> = 29) subgroups. Dietary intake and physical activity (PA) were assessed using a 3-day dietary record and the IPAQ-short form. Blood metabolites were analyzed through multivariate analyses to identify significant differences among the groups, with measurements taken at baseline, 3 months, and 6 months.</p> Results <p>The IHR group exhibited increased dietary fat and fast foods intake, along with enhanced vigorous and moderate PA. Six metabolites were selected as biomarkers that were distinguishable among groups, and the relative serum cholesterol levels significantly decreased in the IHR group at 3 months.</p> Conclusion <p>These results demonstrate that recognizing the BMI-associated genetic risk resulted in a short-term increase in PA but did not improve dietary intake. Increased PA was significantly associated with reduced cholesterol concentration, suggesting the clinical importance of physical activity in the genetically at-risk group.</p> Clinical Trial and Study Registration <p>This study was reviewed and approved by the Seoul National University Institutional Review Board (IRB #1901/001–004) and registered on the Clinical Research Information Service (CRIS), KCT0004650 (<a href="https://cris.nih.go.kr/cris/search/detailSearch.do">https://cris.nih.go.kr/cris/search/detailSearch.do</a> /14091, 2020/01/28).</p>

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Impact of recognition of genetic information related to BMI on changes in physical activity, dietary intake, and blood cholesterol level: a randomized controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月27日

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  • Ga Young Lee,
  • Junghak Lee,
  • Jeong-Han Kim,
  • Kyong-Mee Chung,
  • Sung Nim Han

摘要

Purpose

Genes associated with body mass index (BMI), including FTO rs9939609,MC4R rs17782313, and BDNF rs6265, may influence BMI and regulate energy metabolism. While previous studies have explored health-related behavior changes, few have investigated both biochemical and behavior changes resulting from perceived genetic risk. This study investigated whether recognizing BMI-related genes affects health-related behaviors and alters blood metabolite levels.

Methods

Normal and overweight adults aged 25–35 years (n = 100) were randomly assigned to an intervention group (n = 65) informed about BMI-related genetic information (FTO rs9939609, MC4R rs17782313, BDNF rs6265) and an uninformed group (n = 35, CON). The intervention group was further divided into Intervention-high risk (IHR, n = 36) and intervention-low risk (ILR, n = 29) subgroups. Dietary intake and physical activity (PA) were assessed using a 3-day dietary record and the IPAQ-short form. Blood metabolites were analyzed through multivariate analyses to identify significant differences among the groups, with measurements taken at baseline, 3 months, and 6 months.

Results

The IHR group exhibited increased dietary fat and fast foods intake, along with enhanced vigorous and moderate PA. Six metabolites were selected as biomarkers that were distinguishable among groups, and the relative serum cholesterol levels significantly decreased in the IHR group at 3 months.

Conclusion

These results demonstrate that recognizing the BMI-associated genetic risk resulted in a short-term increase in PA but did not improve dietary intake. Increased PA was significantly associated with reduced cholesterol concentration, suggesting the clinical importance of physical activity in the genetically at-risk group.

Clinical Trial and Study Registration

This study was reviewed and approved by the Seoul National University Institutional Review Board (IRB #1901/001–004) and registered on the Clinical Research Information Service (CRIS), KCT0004650 (https://cris.nih.go.kr/cris/search/detailSearch.do /14091, 2020/01/28).