Scholarlink

Objective <p>Lactoferrin (Lf) expression is upregulated in the brain of patients with Alzheimer’s disease (AD), and mild cognitive impairment (MCI) is recognized as an early, pre-clinical stage of AD. However, the association between serum Lf and MCI remains unclear.</p> Method <p>A cross-sectional study was performed to examine the association between serum Lf and the prevalence of MCI in Chinese adults aged ≥ 40 years. Lf concentrations in serum were measured using an enzyme-linked immunosorbent assay. MCI was diagnosed according to the Chinese version of the mini-mental state examination (MMSE). Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of MCI by quartiles of serum Lf concentrations were estimated using logistic regression. A dose-response relationship was analyzed using a restricted cubic spline. Subgroup analyses were performed by age, sex, weight status, and the presence of diabetes or hypertension, with interaction effects tested.</p> Results <p>Among 1,531 participants (mean age of 59.16 ± 6.35 years), 214 (13.98%) had MCI. The participants with MCI exhibited lower serum Lf concentrations than those without MCI (1.19 ± 0.67&#xa0;µg/mL vs. 1.49 ± 0.75&#xa0;µg/mL, <i>P</i> &lt; 0.001). The MCI prevalence was decreased across ascending quartiles of serum Lf. Compared with the lowest quartile of serum Lf, the multivariable-adjusted OR (95% CI) for MCI prevalence were 0.83 (0.57–1.21), 0.45 (0.29–0.68), and 0.30 (0.19–0.49) with a significant trend (<i>P</i> for trend &lt; 0.001). The restricted cubic spline regression analysis showed an inverted J-shape curve (p for overall &lt; 0.001, p for nonlinear = 0.003). The inverse association persisted regardless of age, gender, and the presence of diabetes and hypertension (all <i>P</i> for trend ≤ 0.01). By weight status, the inverse association was observed in participants with normal weight and overweight (<i>P</i> for trend = 0.002 and &lt; 0.001), but not in those with obesity (<i>P</i> for trend = 0.602). Test of interaction effects indicated that MCI risk decreased more significantly in participants with diabetes than those without diabetes (<i>P</i> for interaction &lt; 0.001).</p> Conclusions <p>Serum Lf was inversely associated with the prevalence of MCI. This association was not observed in participants with obesity, and was more pronounced in those with diabetes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between serum lactoferrin concentrations and the prevalence of mild cognitive impairment among Chinese adults: a cross-sectional study

  • 期刊论文

  • 发表日期：

    2025年7月31日

查看全文
  • Qian He,
  • Zhongxiao Wan,
  • Sumei Yuan,
  • Khemayanto Hidayat,
  • Jia-Ying Xu,
  • Li-Qiang Qin

摘要

Objective

Lactoferrin (Lf) expression is upregulated in the brain of patients with Alzheimer’s disease (AD), and mild cognitive impairment (MCI) is recognized as an early, pre-clinical stage of AD. However, the association between serum Lf and MCI remains unclear.

Method

A cross-sectional study was performed to examine the association between serum Lf and the prevalence of MCI in Chinese adults aged ≥ 40 years. Lf concentrations in serum were measured using an enzyme-linked immunosorbent assay. MCI was diagnosed according to the Chinese version of the mini-mental state examination (MMSE). Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of MCI by quartiles of serum Lf concentrations were estimated using logistic regression. A dose-response relationship was analyzed using a restricted cubic spline. Subgroup analyses were performed by age, sex, weight status, and the presence of diabetes or hypertension, with interaction effects tested.

Results

Among 1,531 participants (mean age of 59.16 ± 6.35 years), 214 (13.98%) had MCI. The participants with MCI exhibited lower serum Lf concentrations than those without MCI (1.19 ± 0.67 µg/mL vs. 1.49 ± 0.75 µg/mL, P < 0.001). The MCI prevalence was decreased across ascending quartiles of serum Lf. Compared with the lowest quartile of serum Lf, the multivariable-adjusted OR (95% CI) for MCI prevalence were 0.83 (0.57–1.21), 0.45 (0.29–0.68), and 0.30 (0.19–0.49) with a significant trend (P for trend < 0.001). The restricted cubic spline regression analysis showed an inverted J-shape curve (p for overall < 0.001, p for nonlinear = 0.003). The inverse association persisted regardless of age, gender, and the presence of diabetes and hypertension (all P for trend ≤ 0.01). By weight status, the inverse association was observed in participants with normal weight and overweight (P for trend = 0.002 and < 0.001), but not in those with obesity (P for trend = 0.602). Test of interaction effects indicated that MCI risk decreased more significantly in participants with diabetes than those without diabetes (P for interaction < 0.001).

Conclusions

Serum Lf was inversely associated with the prevalence of MCI. This association was not observed in participants with obesity, and was more pronounced in those with diabetes.