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Background <p>Mitral valve prolapse (MVP) is commonly benign, but an arrhythmic phenotype (AMVP) with increased risk for sudden cardiac death has been described. A prolonged T<sub>peak</sub>-T<sub>end</sub> interval has been association with increased arrhythmic risk in different clinical settings. The aim of this study was to investigate a possible correlation between prolonged T<sub>peak</sub>-T<sub>end</sub> interval and ventricular tachycardia (VT) inducibility in MVP.</p> Methods and results <p>Sixty-five patients fulfilling the EHRA criteria of AMVP syndrome underwent programmed ventricular stimulation between 2016 and 2024. Sustained polymorphic VT was induced in 19 patients (29.2%) and was significantly associated with prolonged T<sub>peak</sub>-T<sub>end</sub> (100.5 ± 10.3&#xa0;ms vs. 85.1 ± 9.9&#xa0;ms, <i>p</i> = 0.002) and prolonged T<sub>peak</sub>-T<sub>end</sub>/QTc (0.24 ± 0.03 vs. 0.2 ± 0.02, <i>p</i> = 0.004).</p> Conclusion <p>Prolonged T<sub>peak</sub>-T<sub>end</sub> was associated with VT inducibility in patients with AMVP syndrome, suggesting its potential value as simple ECG-based marker for risk stratification. If T<sub>peak</sub>-T<sub>end</sub> also correlates with clinical outcome should be investigated in prospective studies.</p> Graphical Abstract <p></p>

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Tpeak-Tend interval predicts VT inducibility in arrhythmogenic mitral valve prolapse syndrome

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月15日

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  • Benjamin Rath,
  • Julian Wolfes,
  • Christian Ellermann,
  • Fatih Güner,
  • Felix Wegner,
  • Julia Köbe,
  • Florian Reinke,
  • Gerrit Frommeyer,
  • Lars Eckardt

摘要

Background

Mitral valve prolapse (MVP) is commonly benign, but an arrhythmic phenotype (AMVP) with increased risk for sudden cardiac death has been described. A prolonged Tpeak-Tend interval has been association with increased arrhythmic risk in different clinical settings. The aim of this study was to investigate a possible correlation between prolonged Tpeak-Tend interval and ventricular tachycardia (VT) inducibility in MVP.

Methods and results

Sixty-five patients fulfilling the EHRA criteria of AMVP syndrome underwent programmed ventricular stimulation between 2016 and 2024. Sustained polymorphic VT was induced in 19 patients (29.2%) and was significantly associated with prolonged Tpeak-Tend (100.5 ± 10.3 ms vs. 85.1 ± 9.9 ms, p = 0.002) and prolonged Tpeak-Tend/QTc (0.24 ± 0.03 vs. 0.2 ± 0.02, p = 0.004).

Conclusion

Prolonged Tpeak-Tend was associated with VT inducibility in patients with AMVP syndrome, suggesting its potential value as simple ECG-based marker for risk stratification. If Tpeak-Tend also correlates with clinical outcome should be investigated in prospective studies.

Graphical Abstract